Huang Ngan F, Lee Randall J, Li Song
Joint Graduate Group in Bioengineering, University of California San Francisco and University of California Berkeley, Berkeley, California, USA.
Tissue Eng. 2007 Aug;13(8):1809-23. doi: 10.1089/ten.2006.0096.
The field of cardiovascular tissue engineering has experienced tremendous advances in the past several decades, but the clinical reality of engineered heart tissue and vascular conduits remains immature. Stem cells and progenitor cells are promising cell sources for engineering functional cardiovascular tissues. To realize the therapeutic potential of stem cells and progenitor cells, we need to understand how microenvironmental cues modulate and guide stem cell differentiation and organization. This review describes the current understanding of the chemical and physical regulation of embryonic and adult stem cells for potential applications in cardiovascular repair, focusing on cardiac therapies after myocardial infarction and the engineering of vascular conduits.
在过去几十年中，心血管组织工程领域取得了巨大进展，但工程化心脏组织和血管导管的临床应用仍不成熟。干细胞和祖细胞是构建功能性心血管组织的有前景的细胞来源。为了实现干细胞和祖细胞的治疗潜力，我们需要了解微环境信号如何调节和引导干细胞的分化与组织形成。本综述描述了目前对胚胎干细胞和成体干细胞化学及物理调控的理解，这些调控在心血管修复中的潜在应用，重点关注心肌梗死后的心脏治疗以及血管导管的工程构建。
