Wehr T A
Clinical Psychobiology Branch Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland USA 20892.
Br J Psychiatry. 1991 Oct;159:576-8. doi: 10.1192/bjp.159.4.576.
When sleep duration and mood were monitored longitudinally in a 59-year-old woman with bipolar illness, sleep loss appeared to mediate the triggering of mania by psychosocial and pharmacological precipitating factors. This interpretation was supported by observations that mania could repeatedly be induced experimentally by depriving her of sleep for one night. The patient's data illustrate how sleep-loss might be a preventable cause of mania in a variety of situations.
在对一名59岁的双相情感障碍女性患者进行纵向睡眠时长和情绪监测时，睡眠不足似乎介导了社会心理和药物促发因素对躁狂发作的触发作用。这一解释得到了如下观察结果的支持：通过让她连续一晚不睡觉，可反复诱发实验性躁狂发作。该患者的数据表明，在各种情况下，睡眠不足可能是躁狂发作的一个可预防因素。
