Mouridsen Svend Erik, Rich Bente, Isager Torben, Nedergaard Niels Jørgen
Department of Child and Adolescent Psychiatry, Bispebjerg University Hospital, Copenhagen, Denmark.
Dev Med Child Neurol. 2007 Jun;49(6):429-32. doi: 10.1111/j.1469-8749.2007.00429.x.
This register study compared the rates and types of autoimmune disease in the parents of 111 patients (82 males, 29 females; mean age at diagnosis 5y 5mo [SD 2y 6mo]) with infantile autism (IA) with a matched control group of parents of 330 children from the general population. All parents were screened through the nationwide Danish National Hospital Register. We inquired about 35 autoimmune diseases during an observation period of 27 years. At follow-up the case and control mothers were identical in age (65y 7mo [SDs 9y 7mo and 9y respectively]). For case and control fathers the figures were 70 years 2 months (SD 10y 2mo) and 69 years 1 month (SD 10y 1mo) respectively. A similar proportion of case and control mothers had a diagnosis of any autoimmune disease: 10.8% versus 9.1%. For case fathers the proportion was 8.6% versus 4.6%. Two autoimmune conditions were associated with IA: ulcerative colitis in mothers (p=0.05) and type 1 diabetes in fathers (p=0.02). Additional studies are required to determine whether there is a true association between a parental history of autoimmune disease and pervasive developmental disorder in their offspring.
这项登记研究比较了111例婴儿自闭症（IA）患者（82名男性，29名女性；诊断时平均年龄为5岁5个月[标准差2岁6个月]）的父母与来自普通人群的330名儿童的父母组成的匹配对照组中自身免疫性疾病的发生率和类型。所有父母均通过丹麦全国医院登记系统进行筛查。在27年的观察期内，我们询问了35种自身免疫性疾病。随访时，病例组和对照组的母亲年龄相同（分别为65岁7个月[标准差分别为9岁7个月和9岁]）。病例组和对照组父亲的年龄分别为70岁2个月（标准差10岁2个月）和69岁1个月（标准差10岁1个月）。病例组和对照组母亲中被诊断患有任何自身免疫性疾病的比例相似：分别为10.8%和9.1%。病例组父亲的这一比例为8.6%，对照组为4.6%。有两种自身免疫性疾病与婴儿自闭症相关：母亲患溃疡性结肠炎（p=0.05），父亲患1型糖尿病（p=0.02）。需要进一步研究以确定自身免疫性疾病的家族病史与后代广泛性发育障碍之间是否存在真正的关联。
