Mouridsen Svend Erik, Rich Bente, Isager Torben
Department of Child and Adolescent Psychiatry, Bispebjerg University Hospital, Copenhagen 2400, Denmark.
Child Psychiatry Hum Dev. 2008 Mar;39(1):1-8. doi: 10.1007/s10578-007-0062-9. Epub 2007 Jun 13.
In order to study the broader phenotype of infantile autism (IA) we compared the rates and types of epilepsy and other neurological diseases in the parents of 111 consecutively admitted patients with IA with a matched control group of parents of 330 children from the general population. All participants were screened through the nationwide Danish National Hospital Register (DNHR). We inquired about epilepsy and other neurological diseases during an observation period of 27 years. A similar proportion of case- and control mothers had a diagnosis of any neurological disease, 9.9% vs 10.6%. For case fathers the proportion was 5.7% vs 9.7%. No single neurological disease was significantly more frequent among parents of persons with IA. Our study lent support to the notion that epilepsy and other neurological diseases are not part of the broader IA phenotype.
为了研究婴儿自闭症（IA）更广泛的表型，我们将111例连续入院的IA患者的父母中癫痫和其他神经疾病的发病率及类型，与来自普通人群的330名儿童的父母组成的匹配对照组进行了比较。所有参与者均通过丹麦全国医院登记册（DNHR）进行筛查。我们在27年的观察期内询问了癫痫和其他神经疾病情况。病例组和对照组母亲中被诊断患有任何神经疾病的比例相似，分别为9.9%和10.6%。病例组父亲的这一比例为5.7%，对照组为9.7%。IA患者父母中没有单一的神经疾病明显更常见。我们的研究支持了癫痫和其他神经疾病不属于更广泛的IA表型这一观点。
