López-Navidad Antonio, Soler Nuria, Caballero Francisco, Lerma Enrique, Gris Oscar
Department of Organ and Tissue Procurement for Transplantation and Tissue Bank, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.
Transplantation. 2007 May 27;83(10):1345-50. doi: 10.1097/01.tp.0000264199.31913.75.
Acceptance criteria for corneal donation in some eye banks include cadavers with active cancer, both solid and hematological. Such acceptance is based on the fact that the cornea is an avascular tissue and metastatic dissemination is extremely unlikely.
From a total of 588 corneal donors in the Sant Pau Tissue Bank (April 1999 to December 2003), 204 (34.7%) had an active malignancy or a history of malignancy. Of these, 177 had solid cancers and 27 had hematological cancers. Cancer was active in 94.7% and 64% had metastatic dissemination. A histopathological study of the 408 eyes from these 204 donors was performed to rule out metastasis. A total of 325 corneas (79.7%) were transplanted and recipients were followed for an average of 64.1 months (SD 11.1, range 30-86).
The incidence of ocular metastases in the 204 donors with malignancy was 1%, 0.6% for solid cancer, and 3.7% for malignant hematological disease. There was no tumor transmission in any of the 325 recipients.
The incidence of ocular metastases in corneal donors with active malignancy is very low. Donor-recipient tumor transmission through corneal transplantation is highly improbable when the eyes are free of cancer.
一些眼库的角膜捐赠接受标准包括患有实体癌和血液系统癌症的尸体。这种接受基于角膜是无血管组织且极不可能发生转移扩散这一事实。
在圣保禄组织库的588名角膜捐赠者中（1999年4月至2003年12月），204名（34.7%）有活动性恶性肿瘤或恶性肿瘤病史。其中，177名患有实体癌，27名患有血液系统癌症。94.7%的癌症处于活动期，64%有转移扩散。对这204名捐赠者的408只眼睛进行了组织病理学研究以排除转移。共移植了325只角膜（79.7%），对接受者平均随访了64.1个月（标准差11.1，范围30 - 86个月）。
204名患有恶性肿瘤的捐赠者中眼转移的发生率为1%，实体癌为0.6%，恶性血液系统疾病为3.7%。325名接受者中均未发生肿瘤传播。
患有活动性恶性肿瘤的角膜捐赠者中眼转移的发生率非常低。当眼睛无癌症时，通过角膜移植发生供体 - 受体肿瘤传播的可能性极小。
