Yao Xiaoming, Lee Ming, Ying Fangwei, Huang Lina, Qi Wei, Zhao Puning, He Yu-Guang
Department of Ocular Surface Disorders, Shenzhen Ophthalmic Center Affiliated Ji'nan University, Shenzhen, China.
Eye Contact Lens. 2008 Nov;34(6):340-2. doi: 10.1097/ICL.0b013e31818c25d9.
To report a case of corneal transplantation from a donor died of cholangiocarcinoma with metastasis to the eye.
A patient with limbal dermoid received corneal transplant from a donor died of cholangiocarcinoma. Pathologic examination of the remaining donor limbal tissue revealed metastasis of tumor to the limbal vessels. Prompt exchange of the graft was performed. Before the second corneal transplantation, the surrounding tissue of the recipient bed was excised and sent for histopathologic examination.
No tumor transmission was noted surrounding the recipient bed. The second graft remained clear and the patient remained cancer free after regular examination for over a year.
This is the first case to report that cholangiocarcinoma can metastasize to the corneal limbus. To avoid transmission of malignancies from the donor to the recipient, we suggest that donor tissue with history of malignancy should not be used for limbal allografting, and that frozen-section examination of donor limbal tissue is recommended before the transplantation.
报告一例接受来自死于胆管癌且已发生眼转移的供体的角膜移植病例。
一名患有角膜皮样瘤的患者接受了来自死于胆管癌的供体的角膜移植。对剩余供体角膜缘组织进行病理检查发现肿瘤转移至角膜缘血管。迅速更换了移植片。在第二次角膜移植前，切除受体床周围组织并送去做组织病理学检查。
在受体床周围未发现肿瘤传播。第二次移植片保持透明，患者在经过一年多的定期检查后未患癌症。
这是首例报告胆管癌可转移至角膜缘的病例。为避免恶性肿瘤从供体传播至受体，我们建议有恶性肿瘤病史的供体组织不应用于角膜缘同种异体移植，并且建议在移植前对供体角膜缘组织进行冰冻切片检查。
