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靶向线粒体:策略、创新与挑战:未来医学将通过线粒体实现。

Targeting mitochondria: strategies, innovations and challenges: The future of medicine will come through mitochondria.

机构信息

Department of Preventive Medicine, University of Paris 13, ISANH Task Force for Antioxidants Research, Paris, France.

出版信息

Mitochondrion. 2013 Sep;13(5):389-90. doi: 10.1016/j.mito.2013.03.009. Epub 2013 Apr 3.

Abstract

Mitochondrial dysfunction has been associated with the aging process and a large variety of human disorders, such as cardiovascular and neurodegenerative diseases, cancer, migraine, infertility, kidney and liver diseases, toxicity of drugs and many more. It is well recognized that the physiological role of mitochondria widely exceeds that of solely being the biochemical power plant of our cells. Over the recent years, mitochondria have become an interesting target for drug therapy, and the research field aimed at "targeting mitochondria" is active and expanding as witnessed by this already third edition of the world congress on targeting mitochondria. It is becoming a necessity and an urge to know why and how to target mitochondria with bioactive molecules and drugs in order to treat and prevent mitochondria-based pathologies and chronic diseases. This special issue covers a variety of new strategies and innovations as well as clinical applications in mitochondrial medicine.

摘要

线粒体功能障碍与衰老过程以及多种人类疾病有关,如心血管和神经退行性疾病、癌症、偏头痛、不孕、肾脏和肝脏疾病、药物毒性等。人们已经认识到,线粒体的生理作用远远超出了作为我们细胞生化发电厂的作用。近年来,线粒体已成为药物治疗的一个有趣靶点,而以“靶向线粒体”为目标的研究领域正在活跃和扩展,这从第三届世界线粒体靶向大会就可见一斑。为了治疗和预防基于线粒体的疾病和慢性病,有必要也有迫切需要了解为什么以及如何用生物活性分子和药物靶向线粒体。本特刊涵盖了线粒体医学中各种新的策略和创新以及临床应用。

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