Karger Christian P, Jäkel Oliver
Abteilung Medizinische Physik in der Strahlentherapie (E040), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Strahlenther Onkol. 2007 Jun;183(6):295-300. doi: 10.1007/s00066-007-1645-x.
Worldwide, encouraging clinical results of ion radiotherapy led to planning and construction of several new treatment facilities.
The main technical and biological aspects of ion therapy are reviewed. The current status and future developments are discussed.
The use of ions in radiotherapy results in highly conformal dose distributions. The degree of conformality is higher for active than for passive beam delivery techniques. Applying ion therapy, uncertainties in the range and the biologically effective dose have to be considered. For heavy ions, the clinical value of the increased biological efficiency has to be investigated.
Although the principal methods for clinical application of ion therapy are available, the development must be continued to explore its full potential.
在全球范围内，离子放射治疗令人鼓舞的临床结果促使了多个新治疗设施的规划与建设。
对离子治疗的主要技术和生物学方面进行了综述。讨论了其现状和未来发展。
在放射治疗中使用离子可产生高度适形的剂量分布。主动束流传输技术的适形程度高于被动束流传输技术。应用离子治疗时，必须考虑射程和生物有效剂量方面的不确定性。对于重离子，必须研究其提高的生物学效率的临床价值。
尽管离子治疗临床应用的主要方法已经具备，但仍需继续发展以充分发掘其潜力。
