Krombach Gabriele A, Hahn Christa, Tomars Maren, Buecker Arno, Grawe Armin, Günther Rolf W, Kühl Harald P
Department of Diagnostic Radiology, University Hospital, Pauwelsstrasse 30, 52057 Aachen, Germany.
J Magn Reson Imaging. 2007 Jun;25(6):1283-7. doi: 10.1002/jmri.20917.
In cardiac amyloidosis an interstitial deposition of amyloid fibrils causes concentric thickening of the atrial and ventricular walls. We describe the results of tissue characterization of the myocardium by T1 quantification and MRI findings in a patient with cardiac amyloidosis. The T1 time of the myocardium was elevated compared to that in individuals without amyloidosis. The T1 time of the myocardium was 1387 +/- 63 msec (mean value obtained from four measurements +/- standard deviation [SD]) in the patient with cardiac amyloidosis, while the reference value obtained from the myocardium of 10 individuals without known myocardial disease was 1083 +/- 33 msec (mean value +/- SD). In combination with other MR findings suggestive of amyloidosis, such as homogeneous thickening of the ventricular and atrial walls, thickening of the valve leaflets, restrictive filling pattern, and reduction of systolic function, T1 quantification may increase diagnostic confidence.
在心脏淀粉样变性中，淀粉样纤维的间质沉积导致心房和心室壁的同心性增厚。我们描述了通过T1定量对一名心脏淀粉样变性患者的心肌进行组织特征分析的结果以及MRI表现。与无淀粉样变性的个体相比，该患者心肌的T1时间升高。心脏淀粉样变性患者心肌的T1时间为1387±63毫秒（从四次测量获得的平均值±标准差[SD]），而从10名无已知心肌疾病个体的心肌获得的参考值为1083±33毫秒（平均值±SD）。结合其他提示淀粉样变性的MRI表现，如心室和心房壁均匀增厚、瓣膜小叶增厚、限制性充盈模式和收缩功能降低，T1定量可能会提高诊断的可信度。
