Rubel E W, Oesterle E C, Weisleder P
Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle 98195.
Ciba Found Symp. 1991;160:77-96; discussion 96-102. doi: 10.1002/9780470514122.ch5.
The postembryonic production of hair cells in fish and reptiles has been known for several decades. Until recently it was assumed that this capacity was absent in the more highly specialized inner ears of birds and mammals. Recent research has shown, however, that birds have the capacity to rebuild a damaged inner ear. Summarized here are studies conducted in our laboratory which address the following questions: (1) Which are the precursors of the regenerated hair cells? (2) Are the new hair cells functional? (3) What are the ultrastructural properties of regenerated hair cells? and (4) Can the level of proliferation be regulated? Both the auditory and the vestibular systems of the avian inner ear were studied. Our results provide some answers to these questions. The implications of the results are discussed.
鱼类和爬行动物胚胎后毛细胞的产生已为人所知数十年。直到最近，人们还认为鸟类和哺乳动物这种更为高度特化的内耳缺乏这种能力。然而，最近的研究表明，鸟类有能力重建受损的内耳。这里总结了我们实验室进行的研究，这些研究解决了以下问题：（1）再生毛细胞的前体是什么？（2）新的毛细胞有功能吗？（3）再生毛细胞的超微结构特性是什么？以及（4）增殖水平可以调节吗？对鸟类内耳的听觉和前庭系统都进行了研究。我们的结果为这些问题提供了一些答案。并讨论了结果的意义。
