Jurjus Abdo, Atiyeh Bishara S, Abdallah Inaya M, Jurjus Rosalyne A, Hayek Shady N, Jaoude Marlene Abou, Gerges Alice, Tohme Rania A
Human Morphology, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Burns. 2007 Nov;33(7):892-907. doi: 10.1016/j.burns.2006.10.406. Epub 2007 May 22.
Factors involved in wound healing and their interdependence are not yet fully understood; nevertheless, new prospects for therapy to favor speedy and optimal healing are emerging. Reports about wound healing modulation by local application of simple and natural agents abound even in the recent literature, however, most are anecdotal and lack solid scientific evidence. We describe the effect of silver sulfadiazine and moist exposed burn ointment (MEBO), a recently described burn ointment of herbal origin, on mast cells and several wound healing cytokines (bFGF, IL-1, TGF-beta, and NGF) in the rabbit experimental burn model. The results demonstrate that various inflammatory cells, growth factors and cytokines present in the wound bed may be modulated by application of local agents with drastic effects on their expression dynamics with characteristic temporal and spatial regulation and changes in the expression pattern. Such data are likely to be important for the development of novel strategies for wound healing since they shed some light on the potential formulations of temporally and combinatory optimized therapeutic regimens.
伤口愈合所涉及的因素及其相互依存关系尚未完全明了；然而，有利于快速且最佳愈合的治疗新前景正在出现。即使在近期文献中，关于通过局部应用简单天然制剂来调节伤口愈合的报道也比比皆是，然而，大多数都是轶事性的，缺乏确凿的科学证据。我们描述了磺胺嘧啶银和湿润烧伤膏（MEBO，一种最近描述的源自草药的烧伤膏）对兔实验性烧伤模型中肥大细胞和几种伤口愈合细胞因子（碱性成纤维细胞生长因子、白细胞介素 -1、转化生长因子 -β和神经生长因子）的影响。结果表明，伤口床中存在的各种炎症细胞、生长因子和细胞因子可能会受到局部制剂应用的调节，这些制剂对它们的表达动态具有显著影响，具有特征性的时间和空间调节以及表达模式的变化。这些数据对于开发伤口愈合的新策略可能很重要，因为它们为时间和组合优化治疗方案的潜在配方提供了一些线索。
Zotero 插件