Hirsch T, Ashkar W, Schumacher O, Steinstraesser L, Ingianni G, Cedidi C C
Department of Plastic, and Reconstructive Surgery, Helios Klinikum Wuppertal, University of Witten/Herdecke, Germany.
Eur J Med Res. 2008 Nov 24;13(11):505-10.
Wound healing in burn wounds presents a challenge in healthcare, and there is still a lack of alternatives in topical burn wound treatments. - The purpose of this study was to evaluate the efficacy of a new therapeutic ointment (MEBO) in the treatment of partial thickness burns.
40 patients received either topical treatment with Moist Exposed Burn Ointment (MEBO) or standard Flammazine treatment. All patients suffered from partial-thickness burn injuries (< 20% TBSA). Wounds were evaluated for 60 up to days regarding wound healing, water loss, inflammation, and pain alleviation.
For transepidermal water loss, there was a difference of 2.3 gr/m2/h between MEBO, and Flammazine, favoring MEBO. However, this difference was not statistically significant (p=0.78). For all secondary efficacy parameter results were similar. -
This study showed that MEBO ointment for topical treatment of burn injuries presents an attractive alternative for the topical treatment of limited partial thickness thermal burns.
烧伤创面的愈合是医疗保健领域的一项挑战，局部烧伤创面治疗仍缺乏替代方法。本研究的目的是评估一种新型治疗软膏（MEBO）治疗浅Ⅱ度烧伤的疗效。
40例患者分别接受湿润烧伤膏（MEBO）局部治疗或标准磺胺嘧啶银治疗。所有患者均为浅Ⅱ度烧伤（<20%体表面积）。对伤口进行60天的评估，观察伤口愈合、水分流失、炎症和疼痛缓解情况。
对于经表皮水分流失，MEBO与磺胺嘧啶银之间存在2.3克/平方米/小时的差异，MEBO更具优势。然而，这种差异无统计学意义（p=0.78）。所有次要疗效参数的结果相似。
本研究表明，MEBO软膏用于烧伤创面的局部治疗是局限性浅Ⅱ度热烧伤局部治疗的一种有吸引力的替代方法。
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