Abdelraheem Mohamed, Ali El-Tigani, Hussien Rasha, Zijlstra Eduard
Paediatric Nephrology Unit, Soba University Hospital, Khartoum, Sudan.
Toxicol Ind Health. 2011 Nov;27(10):911-3. doi: 10.1177/0748233711399321. Epub 2011 May 4.
A 14-year-old female was referred to the pediatric nephrology unit with a short history of progressive angio-oedema of the face requiring tracheostomy. She ingested an unusual substance which caused swollen tongue, cervical oedema and dark coloured brown urine. These clinical features with the laboratory tests confirmed the diagnosis of paraphenylene diamine (PPD) poisoning. Psychological assessment confirmed that the child had severe depression. The suicide attempt was just immediately after failure in the final qualifying examination to secondary school. She did not have any family support but she used to be punished in different ways. In Sudan PPD in its pure form is available in the local market and until recently there was no restrictions for its use or trade. Adolescents are well aware of its toxic effects and it is commonly used to attempt suicide. Legislation and laws should prevent its use in different hair dye formulations and look for another substitute. Clinical management is hampered by the lack of a rapid diagnostic test; no other treatment other than supportive measures can be offered.
一名14岁女性因面部进行性血管性水肿病史较短且需要气管切开术而被转诊至儿科肾病科。她摄入了一种不寻常的物质，导致舌头肿胀、颈部水肿和深褐色尿液。这些临床特征以及实验室检查确诊为对苯二胺（PPD）中毒。心理评估证实该儿童患有严重抑郁症。自杀企图发生在中学毕业资格考试失败后不久。她没有任何家庭支持，还经常受到各种形式的惩罚。在苏丹，纯形式的PPD在当地市场有售，直到最近对其使用或交易都没有限制。青少年深知其毒性作用，它常被用于自杀企图。立法应禁止其在不同染发剂配方中的使用，并寻找其他替代品。由于缺乏快速诊断测试，临床管理受到阻碍；除了支持性措施外，无法提供其他治疗方法。
