健康志愿者短期采用旧石器时代饮食干预的效果。
Effects of a short-term intervention with a paleolithic diet in healthy volunteers.
作者信息
Osterdahl M, Kocturk T, Koochek A, Wändell P E
机构信息
Department of Neurobiology, Center for Family and Community Medicine, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
出版信息
Eur J Clin Nutr. 2008 May;62(5):682-5. doi: 10.1038/sj.ejcn.1602790. Epub 2007 May 16.
OBJECTIVES
Prevention of cardiovascular diseases by paleolithic or hunter-gatherer diets has been discussed during recent years.
METHODS
Our aim was to assess the effect of a paleolithic diet in a pilot study on healthy volunteers during 3 weeks. The intention was to include 20 subjects, of whom 14 fulfilled the study. Complete dietary assessment was available for six subjects.
RESULTS
Mean weight decreased by 2.3 kg (P<0.001), body mass index by 0.8 (P<0.001), waist circumference by 0.5 cm (P=0.001), systolic blood pressure by 3 mm Hg (P=0.03) and plasminogen activator inhibitor-1 by 72% (P=0.020). Regarding nutrient intake, intake of energy decreased by 36%, and other effects were also observed, both favourable (fat composition, antioxidants, potassium-sodium rate) and unfavourable (calcium).
CONCLUSION
This short-term intervention showed some favourable effects by the diet, but further studies, including control group, are needed.
目的
近年来，关于旧石器时代饮食或狩猎采集者饮食对心血管疾病的预防作用一直备受讨论。
方法
我们的目的是在一项针对健康志愿者的试点研究中，评估旧石器时代饮食在3周内的效果。原本计划纳入20名受试者，其中14名完成了研究。6名受试者有完整的饮食评估数据。
结果
平均体重下降了2.3千克（P<0.001），体重指数下降了0.8（P<0.001），腰围下降了0.5厘米（P=0.001），收缩压下降了3毫米汞柱（P=0.03），纤溶酶原激活物抑制剂-1下降了72%（P=0.020）。在营养摄入方面，能量摄入下降了36%，还观察到了其他一些有利（脂肪组成、抗氧化剂、钾钠比）和不利（钙）的影响。
结论
这项短期干预显示该饮食有一些有利影响，但需要进一步开展包括对照组在内的研究。
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