[肥胖儿童和青少年血脂异常的危险因素]
[Risk factors for dislypidemia in obese children and adolescents].
作者信息
Romero-Velarde Enrique, Campollo-Rivas Octavio, Celis de la Rosa Alfredo, Vásquez-Garibay Edgar M, Castro-Hernández Juan Francisco, Cruz-Osorio Rosa M
机构信息
Instituto de Nutrición Humana, Departamento de Reproduccion Humana, Crecimiento y Desarrollo Infantil.
出版信息
Salud Publica Mex. 2007 Mar-Apr;49(2):103-8. doi: 10.1590/s0036-36342007000200005.
OBJECTIVE
To assess the risk of dislypidemia associated with obesity in children and adolescents.
MATERIAL AND METHODS
A cross sectional study was conducted with 62 obese children (BMI > 95 centile and tricipital skinfold thickness > 90 centile) and 70 non-obese children (BMI 5-85 centile) ages 5-15 years, without chronic diseases. Subjects' characteristics and family background of chronic diseases were collected and a lipid profile was determined. The risk of lipid alterations in the obese children was calculated using odds ratio (OR) and multivariate analysis.
RESULTS
Mean age was 9.8 +/- 2.7 years in both groups; 63 girls and 69 boys were included. Obesity was associated with abnormal values for cholesterol, triglycerides, LDL, HDL and dislypidemia (> 1 abnormal value) (OR 4.47-15.0). In obese children and adolescents the multivariate analysis showed that female gender was associated with dislypidemia.
CONCLUSION
Obesity in children and adolescents is associated with high risk of dislypidemia; the risk is higher among females.
目的
评估儿童和青少年肥胖与血脂异常相关的风险。
材料与方法
对62名肥胖儿童（BMI>第95百分位数且三头肌皮褶厚度>第90百分位数）和70名5至15岁无慢性疾病的非肥胖儿童（BMI为第5至85百分位数）进行了一项横断面研究。收集受试者的特征和慢性疾病家族史，并测定血脂谱。使用比值比（OR）和多变量分析计算肥胖儿童血脂改变的风险。
结果
两组的平均年龄均为9.8±2.7岁；纳入了63名女孩和69名男孩。肥胖与胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白和血脂异常（>1个异常值）的异常值相关（OR为4.47 - 15.0）。在肥胖儿童和青少年中，多变量分析显示女性性别与血脂异常相关。
结论
儿童和青少年肥胖与血脂异常的高风险相关；女性的风险更高。
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