Kofoed Kristian, Sand Carsten, Forslund Ola, Madsen Klaus
Department of Dermatovenereology, Copenhagen University Hospital, Bispebjerg, DK-2400 Copenhagen, Denmark.
Acta Derm Venereol. 2014 Mar;94(2):207-11. doi: 10.2340/00015555-1718.
Genital warts are caused by human papillomavirus (HPV). HPV is a leading cause of anogenital malignancies and a role of HPV in the aetiology of oro-pharyngeal cancers has been demonstrated. The frequency of oral HPV infection in patients with genital warts and the association between concomitant genital, anal and oral infection is unclear. A total of 201 men and women with genital wart-like lesions were recruited. Swab samples were obtained from the genital warts and the anal canal and an oral rinse was collected. Anal HPV was found in 46.2% and oral HPV in 10.4% of the participants. Concordance between anal and genital wart HPV types was 78.1%, while concordance between oral and genital wart types was 60.9%. A lower concordance of 21.7% was observed between anal and oral HPV types. Significantly more women than men had multiple HPV types and anal HPV. In conclusion, extra genital HPV is common in patients with genital warts. A gender inequality seems to exist.
尖锐湿疣由人乳头瘤病毒（HPV）引起。HPV是肛门生殖器恶性肿瘤的主要病因，并且HPV在口咽癌病因学中的作用已得到证实。尖锐湿疣患者口腔HPV感染的频率以及生殖器、肛门和口腔同时感染之间的关联尚不清楚。共招募了201名有生殖器疣样病变的男性和女性。从尖锐湿疣和肛管采集拭子样本，并收集口腔冲洗液。46.2%的参与者检测到肛门HPV，10.4%检测到口腔HPV。肛门和生殖器疣HPV类型之间的一致性为78.1%，而口腔和生殖器疣类型之间的一致性为60.9%。肛门和口腔HPV类型之间的一致性较低，为21.7%。感染多种HPV类型和肛门HPV的女性明显多于男性。总之，生殖器外HPV在尖锐湿疣患者中很常见。似乎存在性别不平等现象。
