Hosseini Seyed Nejat, Mousavinasab Seyed Nouraddin, Fallahnezhat Mojtaba
Shafieeh hospital, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Burns. 2007 Sep;33(6):776-81. doi: 10.1016/j.burns.2006.10.396. Epub 2007 May 23.
In many countries the standard treatment of second degree burns includes the use of local antibacterial agents, frequent debridement of the wound, and frequent dressing changes, which are debilitating and costly. Since accurate information about alternative cures is scanty, this study was conducted to assess the outcome of the use of xenoderm biologic dressings as one alternative.
This descriptive, goal-oriented sampling study was performed on 97 subjects suffering from deep partial thickness burns. Additionally, some of them had superficial and third degree burns. The patients underwent surgical operation and xenoderm dressings. The outcome of xenoderm application was considered such as frequency of dressings, hospital stay, the duration of analgesia use, wound infection, and the formation of granulation and scars at the burns site.
The results of this study indicate that the mean hospital stay from the time the patients were referred to the emergency ward was 6.45+/-5.51 days and it was 4.69+/-5.51 days from the time the operation was performed. The mean frequency of dressings in the interval between the use of xenoderm and the patients' discharge was 1.51+/-1.60 times. 22.9% (22 patients) of the patients did not take any analgesic after the operation. 27.1% of the patients had superficial infection at the burns site. Granulation tissue was observed in 46.9% of the patients.
The finding of the present study suggest that the use of xenoderm reduces the frequency of the dressings, Hospital stay, pain and analgesic. Therefore, the use of xenoderm in the treatment of second degree burns is recommended.
在许多国家，二度烧伤的标准治疗包括使用局部抗菌剂、频繁清创伤口以及频繁更换敷料，这些方法既让人虚弱又成本高昂。由于关于替代疗法的准确信息匮乏，本研究旨在评估使用异种皮肤生物敷料作为一种替代方法的效果。
本描述性、目标抽样研究对97名深二度烧伤患者进行。此外，其中一些患者还伴有浅度和三度烧伤。患者接受了手术及异种皮肤敷料治疗。异种皮肤应用的效果评估包括敷料更换频率、住院时间、使用镇痛剂的时长、伤口感染情况以及烧伤部位肉芽组织和瘢痕的形成情况。
本研究结果表明，患者从被送往急诊病房到出院的平均住院时间为6.45±5.51天，从手术开始到出院的平均住院时间为4.69±5.51天。在使用异种皮肤敷料至患者出院期间，敷料更换的平均频率为1.51±1.60次。22.9%（22名患者）的患者术后未使用任何镇痛剂。27.1%的患者烧伤部位出现浅表感染。46.9%的患者观察到肉芽组织形成。
本研究结果表明，使用异种皮肤可减少敷料更换频率、住院时间、疼痛及镇痛剂使用。因此，建议在二度烧伤治疗中使用异种皮肤。
