Ganji M R, Charkhchian M, Hakemi M, Nederi G H, Solymanian T, Saddadi F, Amini M, Najafi I
Nephrology Department, Tehran University of Medical Sciences, Tehran, Iran.
Transplant Proc. 2007 May;39(4):852-4. doi: 10.1016/j.transproceed.2007.03.030.
Hyperglycemia is common following renal transplantation. This study was conducted to evaluate the relationship of perioperative serum glucose levels and acute rejection in 100 nondiabetic patients who underwent renal transplantation. Blood glucose was measured immediately following surgery and every 6 hours during the first 48 hours posttransplant as well as for 1 month to evaluate occurrence of acute rejection episodes (ARE). The rate of ARE was 33%. The mean blood glucose level immediately after surgery in patients with versus without ARE was 249.67 +/- 61.78 and 184.82 +/- 73.35 mg/dL, respectively (P=.000). There was no significant correlation between ARE and donor or recipient age or sex, delayed graft function, type of donor, or treatment. This study suggested a correlation between immediate blood glucose and ARE. In this regard, blood glucose monitoring and control during operation and immediate postoperatively may reduce the acute rejection rate.
肾移植后高血糖很常见。本研究旨在评估100例接受肾移植的非糖尿病患者围手术期血清葡萄糖水平与急性排斥反应之间的关系。术后立即测量血糖，并在移植后的头48小时内每6小时测量一次，持续1个月，以评估急性排斥反应发作（ARE）的发生情况。ARE发生率为33%。发生ARE与未发生ARE的患者术后即刻平均血糖水平分别为249.67±61.78和184.82±73.35mg/dL（P = 0.000）。ARE与供体或受体的年龄、性别、移植肾功能延迟、供体类型或治疗之间无显著相关性。本研究表明即刻血糖与ARE之间存在相关性。在这方面，术中及术后即刻进行血糖监测和控制可能会降低急性排斥反应率。
