List A, Nazar B, Nyquist S, Harclerode J
Drug Metab Dispos. 1977 May-Jun;5(3):268-72.
The effects of delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on hydroxylation of estradiol and testosterone in rat liver microsomes were investigated. Acute and chronic treatment of male and female rats with either cannabinoid, 2 or 10 mg/kg, significantly elevated steroid hydroxylase activity. Acute administration of THC or CBD, 10 mg/kg, evoked no detectable changes in cytochrome P-450 levels, but a significant decrease in those of cytochrome b5. Chronic administration of THC or CBD, 2 mg/kg, decreased levels of cytochrome P-450, whereas cytochrome b5 levels appeared normal. Acute doses of THC or CBD at 10 mg/kg significantly depressed testosterone formation in testis microsomes. Chronic THC, 2 mg/kg, but not CBD, evoked the most dramatic decrease in testicular enzyme activity.
研究了δ9-四氢大麻酚（THC）和大麻二酚（CBD）对大鼠肝微粒体中雌二醇和睾酮羟基化的影响。用2或10mg/kg的任一一种大麻素对雄性和雌性大鼠进行急性和慢性处理，均显著提高了类固醇羟化酶活性。急性给予10mg/kg的THC或CBD，未引起细胞色素P-450水平的可检测变化，但细胞色素b5水平显著降低。慢性给予2mg/kg的THC或CBD，降低了细胞色素P-450水平，而细胞色素b5水平似乎正常。10mg/kg的急性剂量THC或CBD显著抑制睾丸微粒体中睾酮的形成。慢性给予2mg/kg的THC而非CBD，引起睾丸酶活性最显著的下降。
