玻璃体内注射曲安奈德后发生的单纯疱疹性角膜炎。
Herpes simplex keratitis after intravitreal triamcinolone acetonide.
作者信息
Shtein Roni M, Stahl Roslyn M, Saxe Stephen J, Mian Shahzad I
机构信息
Department of Ophthalmology and Visual Sciences, University of Michigan, W.K. Kellogg Eye Center, Ann Arbor, MI, USA.
出版信息
Cornea. 2007 Jun;26(5):641-2. doi: 10.1097/ICO.0b013e318041f0c0.
PURPOSE
To report a case of recurrent herpes simplex virus (HSV) epithelial keratitis after intravitreal triamcinolone acetonide injection for the treatment of diabetic macular edema.
METHODS
Case report.
RESULTS
We describe a case of a 59-year-old woman with a history of ocular HSV disease and severe proliferative diabetic retinopathy. She received an intravitreal injection of triamcinolone acetonide for macular edema in the right eye. One week later, she developed foreign body sensation, redness, and photophobia in the same eye. Slit-lamp examination revealed a corneal epithelial dendritic lesion. She was diagnosed with a recurrence of HSV epithelial keratitis and was treated with oral acyclovir 400 mg, 5 times a day, with good resolution of HSV signs and symptoms.
CONCLUSIONS
Intravitreal triamcinolone acetonide injection may result in reactivation of HSV keratitis.
目的
报告1例玻璃体内注射曲安奈德治疗糖尿病性黄斑水肿后复发性单纯疱疹病毒（HSV）上皮性角膜炎的病例。
方法
病例报告。
结果
我们描述了1例59岁女性，有眼部HSV疾病史和严重增生性糖尿病视网膜病变。她右眼因黄斑水肿接受了玻璃体内曲安奈德注射。1周后，她同一眼出现异物感、眼红和畏光。裂隙灯检查发现角膜上皮树枝状病变。她被诊断为HSV上皮性角膜炎复发，并接受口服阿昔洛韦400mg，每日5次治疗，HSV的体征和症状得到良好缓解。
结论
玻璃体内注射曲安奈德可能导致HSV角膜炎复发。
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