Gulkilik Gokhan, Demirci Goktug, Ozdamar Akif M, Muftuoglu Gul I
Vakif Gureba Education Hospital, Eye Clinic, Istanbul, Turkey.
Cornea. 2007 Sep;26(8):1000-1. doi: 10.1097/ICO.0b013e3180cab659.
We report a case of herpetic epithelial keratitis that developed after intravitreal triamcinolone acetonide injection.
An 81-year-old man with diabetes with severe nonproliferative diabetic retinopathy and diffuse macular edema in both eyes received bilateral intravitreal injections of 0.4 mg/0.1 mL of triamcinolone acetonide.
Eighteen days after the injections, the patient presented with redness, tearing, foreign body sensation, and decreased visual acuity in the right eye. The cornea showed dendriform ulcers that exhibited positive fluorescein staining. Diagnosis for herpes simplex epithelial keratitis was made, and topical acyclovir ointment therapy was initiated. The epithelial lesions healed after 7 days of therapy.
Herpes simplex epithelial keratitis can be a possible complication of intravitreal triamcinolone acetonide injection. The course and response to conventional therapy was no different from that of the classical course of the disease.
我们报告一例玻璃体内注射曲安奈德后发生的疱疹性上皮性角膜炎病例。
一名81岁患有糖尿病且双眼患有严重非增殖性糖尿病视网膜病变和弥漫性黄斑水肿的男性接受了双侧玻璃体内注射0.4mg/0.1mL曲安奈德。
注射后18天,患者右眼出现眼红、流泪、异物感及视力下降。角膜可见树枝状溃疡,荧光素染色阳性。诊断为单纯疱疹性上皮性角膜炎,并开始局部使用阿昔洛韦眼膏治疗。治疗7天后上皮病变愈合。
单纯疱疹性上皮性角膜炎可能是玻璃体内注射曲安奈德的一种并发症。其病程及对传统治疗的反应与该疾病的经典病程无异。