O'Garra Anne, Vieira Paulo
Division of Immunoregulation, The National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.
Nat Rev Immunol. 2007 Jun;7(6):425-8. doi: 10.1038/nri2097.
Inflammatory T helper 1 (T(H)1)-cell responses successfully eradicate pathogens, but often also cause immunopathology. To minimize this deleterious side-effect the anti-inflammatory cytokine interleukin-10 (IL-10) is produced. Although IL-10 was originally isolated from T(H)2 cells it is now known to be produced by many cell types. Here, we discuss the recent evidence that shows that T(H)1 cells are the main source of IL-10 that controls the immune response against Leishmania major and Toxoplasma gondii infection.
炎症性辅助性T细胞1（T(H)1）反应能够成功根除病原体，但往往也会引发免疫病理反应。为了将这种有害的副作用降至最低，会产生抗炎细胞因子白细胞介素10（IL-10）。尽管IL-10最初是从T(H)2细胞中分离出来的，但现在已知它可由多种细胞类型产生。在此，我们讨论最近的证据，这些证据表明T(H)1细胞是控制针对硕大利什曼原虫和刚地弓形虫感染的免疫反应的IL-10的主要来源。
