Frank Guido K, Bailer Ursula F, Meltzer Carolyn C, Price Julie C, Mathis Chester A, Wagner Angela, Becker Carl, Kaye Walter H
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
Int J Eat Disord. 2007 Sep;40(6):488-92. doi: 10.1002/eat.20395.
Abnormalities of regional cerebral blood flow (rCBF) have been found in individuals who are ill with anorexia (AN) or bulimia nervosa (BN). Little is known about whether rCBF normalizes after recovery from AN and BN.
Eighteen control women (CW), 10 recovered restricting type AN, 8 recovered AN with a binging history, and 9 recovered BN participants without a history of AN were studied using positron emission tomography and [(15)O]water in order to assess rCBF.
Partial volume corrected rCBF values in cortical and subcortical brain regions were similar between groups. Neither current body mass index nor age correlated with rCBF values.
The results from this study indicate that rCBF normalizes with long-term recovery. Thus, altered rCBF is unlikely to confound functional imaging studies in AN or BN after recovery.
在患有神经性厌食症（AN）或神经性贪食症（BN）的个体中发现了局部脑血流量（rCBF）异常。对于AN和BN康复后rCBF是否恢复正常知之甚少。
使用正电子发射断层扫描和[（15）O]水对18名对照女性（CW）、10名康复的限制型AN患者、8名有暴饮暴食史的康复AN患者以及9名无AN病史的康复BN参与者进行研究，以评估rCBF。
各组之间皮质和皮质下脑区的部分容积校正rCBF值相似。当前体重指数和年龄均与rCBF值无关。
本研究结果表明，rCBF随长期康复而恢复正常。因此，rCBF改变不太可能混淆AN或BN康复后功能成像研究的结果。
