Ferrières Lionel, Hancock Viktoria, Klemm Per
Microbial Adhesion Group, Center for Biomedical Microbiology, BioCentrum-DTU, Technical University of Denmark, Lyngby, Denmark.
Microbiology (Reading). 2007 Jun;153(Pt 6):1711-1719. doi: 10.1099/mic.0.2006/004721-0.
Many bacterial infections are associated with biofilm formation. In the urinary tract bacterial biofilms develop on both living surfaces and artificial implants, producing chronic and often intractable infections. Escherichia coli is the most common organism associated with urinary tract infections. In contrast to uropathogenic E. coli (UPEC), which cause symptomatic urinary tract infection, asymptomatic bacteriuria (ABU) strains are associated with essentially symptom-free infections. Here the biofilm-forming capacity on abiotic surfaces of selected E. coli ABU strains and UPEC strains in human urine was investigated. It was found that there is a strong bias for biofilm formation by the ABU strains. Not only were the ABU strains significantly better biofilm formers than UPEC strains, they were also able to out-compete UPEC strains as well as uropathogenic strains of Klebsiella spp. during biofilm formation. The results support the notion of bacterial prophylaxis employing selected ABU strains to eliminate UPEC strains and other pathogens in patients prone to recalcitrant infections.
许多细菌感染都与生物膜形成有关。在泌尿系统中，细菌生物膜在活体表面和人工植入物上形成，引发慢性且往往难以治疗的感染。大肠杆菌是与泌尿系统感染相关的最常见病原体。与导致有症状泌尿系统感染的尿路致病性大肠杆菌（UPEC）不同，无症状菌尿（ABU）菌株引发的感染基本无症状。在此，研究了人尿液中选定的大肠杆菌ABU菌株和UPEC菌株在非生物表面形成生物膜的能力。结果发现，ABU菌株在生物膜形成方面存在强烈偏好。ABU菌株不仅比UPEC菌株形成生物膜的能力显著更强，而且在生物膜形成过程中，它们还能够胜过UPEC菌株以及肺炎克雷伯菌属的尿路致病性菌株。这些结果支持了利用选定的ABU菌株进行细菌预防以消除易患顽固性感染患者体内UPEC菌株和其他病原体的观点。
