先天性免疫对膀胱感染的反应。
Innate Immune Responses to Bladder Infection.
机构信息
Departments of Pathology.
Molecular Genetics and Microbiology.
出版信息
Microbiol Spectr. 2016 Dec;4(6). doi: 10.1128/microbiolspec.UTI-0024-2016.
Abstract
Urinary tract infections are one of the most frequent bacterial infections of mankind. In spite of this frequency, the study of the immune system in the urinary tract has not attracted much attention. This could, in part, be attributable to the widespread use of antibiotics and similar antimicrobial agents, which for many decades have been both highly effective and relatively inexpensive to administer. In light of the emergence of multidrug-resistant bacteria among urinary tract infection isolates, interest in understanding the immune system in the urinary tract has grown. Several recent studies have revealed the existence of a powerful and highly coordinated innate immune system in the urinary tract designed to rapidly clear infecting pathogens; however, it also evokes harmful side effects.
摘要
尿路感染是人类最常见的细菌性感染之一。尽管这种感染很常见，但尿路免疫系统的研究并没有引起太多关注。部分原因可能是抗生素和类似抗菌药物的广泛使用，这些药物在过去几十年中既非常有效，又相对便宜。鉴于尿路感染分离株中出现了多药耐药菌，人们对了解尿路免疫系统的兴趣日益增加。最近的几项研究揭示了尿路中存在一种强大而高度协调的先天免疫系统，旨在迅速清除感染病原体；然而，它也会引起有害的副作用。
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本文引用的文献
1
What Keeps the Urinary Tract Sterile?: The Antimicrobial Peptide Cathelicidin Protects the Urinary Tract against Invasive Bacterial Infection. Nat Med 12: 636-640, 2006.是什么维持尿路无菌？抗菌肽Cathelicidin保护尿路免受侵袭性细菌感染。《自然医学》12卷：636 - 640页，2006年。
J Am Soc Nephrol. 2006 Dec;17(12):3267-3272. doi: 10.1681/01.asn.0000926856.92699.53.
2
Ubiquitination of Innate Immune Regulator TRAF3 Orchestrates Expulsion of Intracellular Bacteria by Exocyst Complex.固有免疫调节因子TRAF3的泛素化通过外泌体复合物协调细胞内细菌的排出。
Immunity. 2016 Jul 19;45(1):94-105. doi: 10.1016/j.immuni.2016.06.023.
3
Detection of intracellular bacteria in exfoliated urothelial cells from women with urge incontinence.急迫性尿失禁女性脱落尿路上皮细胞内细菌的检测
Pathog Dis. 2016 Oct;74(7). doi: 10.1093/femspd/ftw067. Epub 2016 Jul 7.
4
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Int Neurourol J. 2015 Sep;19(3):142-50. doi: 10.5213/inj.2015.19.3.142. Epub 2015 Sep 22.
5
Macrophages Subvert Adaptive Immunity to Urinary Tract Infection.巨噬细胞破坏对尿路感染的适应性免疫。
PLoS Pathog. 2015 Jul 16;11(7):e1005044. doi: 10.1371/journal.ppat.1005044. eCollection 2015 Jul.
6
Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis.环氧化酶-2 的抑制可预防慢性和复发性膀胱炎。
EBioMedicine. 2014 Oct 24;1(1):46-57. doi: 10.1016/j.ebiom.2014.10.011. eCollection 2014 Nov.
7
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J Infect. 2015 Sep;71(3):358-367. doi: 10.1016/j.jinf.2015.05.014. Epub 2015 Jun 3.
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Cell. 2015 Jun 4;161(6):1306-19. doi: 10.1016/j.cell.2015.05.009. Epub 2015 May 28.
9
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Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):E871-80. doi: 10.1073/pnas.1500374112. Epub 2015 Feb 9.
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