Guyatt Gordon, Schunemann Holger
CLARITY Research Group, Department of Clinical Epidemiology and Biostatistics, Health Sciences Centre, McMaster University, 1200 Main Street West, Rm. HSC 2C12, Hamilton, ON, Canada, L8N 3Z5.
Qual Life Res. 2007 Sep;16(7):1097-105. doi: 10.1007/s11136-007-9223-3. Epub 2007 May 26.
To make optimal use of data from randomized trials in clinical decision-making, clinicians require knowledge of the magnitude of treatment effects. Reports of trials including quality of life data often fail to report results that provide interpretable estimates of magnitude of effect. Strategies that investigators could use to remedy this problem include reporting mean differences between groups in relation to the minimal important difference and reporting the proportion of patients who benefit from treatment and the associated number needed to treat. Techniques are available that allow investigators to use the same strategies in reporting pooled estimates from meta-analyses, even when studies use different instruments to measure the same construct. These reporting approaches, as well as ensuring access to data from individual items, will also help those developing decision aids to use quality of life data.
为了在临床决策中最佳地利用随机试验的数据,临床医生需要了解治疗效果的大小。包含生活质量数据的试验报告往往未能报告能提供可解释的效果大小估计值的结果。研究人员可用于解决这一问题的策略包括报告组间平均差异与最小重要差异的关系,以及报告从治疗中获益的患者比例和相关的需治疗人数。现有技术使研究人员能够在报告荟萃分析的汇总估计值时采用相同的策略,即使各研究使用不同的工具来测量同一结构。这些报告方法,以及确保获取单个项目的数据,也将有助于那些开发决策辅助工具的人使用生活质量数据。