Szelest-Lewandowska A, Masiulanis B, Szymonowicz M, Pielka S, Paluch D
Faculty of Chemistry, Department of Polymer Technology, Gdańsk University of Technology, 80-952 Gdańsk, Poland.
J Biomed Mater Res A. 2007 Aug;82(2):509-20. doi: 10.1002/jbm.a.31357.
A new polycarbonate urethane (PCU-I) was synthesized from aliphatic monomers, i.e. polyhexamethylene carbonate diol and 4,4'-methylene-bis cyclohexane diisocyanate, a mixture of low molecular diols, and castor oil (containing mainly the triglyceride of 12-hydroxyoleic acid). The second synthesized polymer (PCU-II) did not contain castor oil. Both PCUs had good tensile strength, i.e. 32.5 and 27.8 MPa for PCU-I and PCU-II, respectively. Modification by castor oil led to a decrease in glass transition temperature (T(g) = -14 degrees C for PCU-I and -6 degrees C for PCU-II) and an increase in the softening temperature (135 and 125 degrees C for PCU-I and PCU-II, respectively). Partial crosslinking of PCU-I increased the storage modulus of elasticity and provided better resistance to sterilization by ETO and gamma radiation. Both PCUs displayed good stability when subjected to sterilization by hydrogen peroxide plasma. Neither PCU caused cytotoxic effect in mouse fibroblasts (3T3 Balb C). They also had no toxic effects on the morphotic components and did not influence changes in the hematologic parameters or plasmatic coagulation system of human blood.
一种新型聚碳酸酯聚氨酯（PCU-I）由脂肪族单体合成，即聚己二酸己二醇酯和4,4'-亚甲基双环己基二异氰酸酯、低分子二醇混合物以及蓖麻油（主要含有12-羟基油酸甘油三酯）。合成的第二种聚合物（PCU-II）不含蓖麻油。两种PCU均具有良好的拉伸强度，PCU-I和PCU-II的拉伸强度分别为32.5 MPa和27.8 MPa。蓖麻油改性导致玻璃化转变温度降低（PCU-I为-14℃，PCU-II为-6℃），软化温度升高（PCU-I和PCU-II分别为135℃和125℃）。PCU-I的部分交联提高了储能模量，并对环氧乙烷和γ射线灭菌具有更好的耐受性。两种PCU在过氧化氢等离子体灭菌时均表现出良好的稳定性。两种PCU在小鼠成纤维细胞（3T3 Balb C）中均未引起细胞毒性作用。它们对形态学成分也没有毒性作用，并且不影响人体血液的血液学参数或血浆凝血系统的变化。
