Rogerson Shane, Weatherby Robert P, Deakin Glen B, Meir Rudi A, Coutts Rosanne A, Zhou Shi, Marshall-Gradisnik Sonya M
School of Exercise and Sport Management, Southern Cross University, Lismore, New Wales, Australia.
J Strength Cond Res. 2007 May;21(2):354-61. doi: 10.1519/R-18385.1.
Use of testosterone enanthate has been shown to significantly increase strength within 6-12 weeks of administration (2, 9), however, it is unclear if the ergogenic benefits are evident in less than 6 weeks. Testosterone enanthate is classified as a prohibited substance by the World Anti-Doping Agency (WADA) and its use may be detected by way of the urinary testosterone/epitestosterone (T/E) ratio (16). The two objectives of this study were to establish (a) if injection of 3.5 mg.kg(-1) testosterone enanthate once per week could increase muscular strength and cycle sprint performance in 3-6 weeks; and (b) if the WADA-imposed urinary T/E ratio of 4:1 could identify all subjects being administered 3.5 mg.kg(-1) testosterone enanthate. Sixteen healthy young men were match-paired and were assigned randomly in a double-blind manner to either a testosterone enanthate or a placebo group. All subjects performed a structured heavy resistance training program while receiving either testosterone enanthate (3.5 mg.kg(-1)) or saline injections once weekly for 6 weeks. One repetition maximum (1RM) strength measures and 10-second cycle sprint performance were monitored at the pre (week 0), mid (week 3), and post (week 6) time points. Body mass and the urinary T/E ratio were measured at the pre (week 0) and post (week 6) time points. When compared with baseline (pre), 1RM bench press strength and total work during the cycle sprint increased significantly at week 3 (p < 0.01) and week 6 (p < 0.01) in the testosterone enanthate group, but not in the placebo group. Body mass at week 6 was significantly greater than at baseline in the testosterone enanthate group (p < 0.01), but not in the placebo group. Despite the clear ergogenic effects of testosterone enanthate in as little as 3 weeks, 4 of the 9 subjects in the testosterone enanthate group ( approximately 44%) did not test positive to testosterone under current WADA urinary T/E ratio criteria.
已证明使用庚酸睾酮在给药6至12周内可显著增强力量(2, 9)，然而，尚不清楚在少于6周的时间内是否能明显体现出其增强体能的益处。庚酸睾酮被世界反兴奋剂机构（WADA）列为违禁物质，其使用情况可通过尿液中睾酮/表睾酮（T/E）比值检测出来(16)。本研究的两个目的是确定：(a) 每周注射一次3.5 mg·kg⁻¹庚酸睾酮是否能在3至6周内增强肌肉力量和自行车冲刺成绩；以及(b) WADA规定的尿液T/E比值4:1是否能识别所有接受3.5 mg·kg⁻¹庚酸睾酮注射的受试者。16名健康青年男性进行匹配配对，并以双盲方式随机分为庚酸睾酮组或安慰剂组。所有受试者在接受每周一次的庚酸睾酮（3.5 mg·kg⁻¹）或生理盐水注射，为期6周的同时，进行结构化的大强度抗阻训练计划。在训练前（第0周）、训练中期（第3周）和训练后（第6周）时间点监测一次最大重复次数（1RM）力量指标和10秒自行车冲刺成绩。在训练前（第0周）和训练后（第6周）时间点测量体重和尿液T/E比值。与基线（训练前）相比，庚酸睾酮组在第3周（p < 0.01）和第6周（p < 0.01）时，1RM卧推力量和自行车冲刺期间的总功显著增加，而安慰剂组则无此变化。庚酸睾酮组第6周时的体重显著高于基线水平（p < 0.01），而安慰剂组则无此变化。尽管庚酸睾酮在短短3周内就有明显的增强体能效果，但在庚酸睾酮组的9名受试者中，有4名（约44%）根据当前WADA尿液T/E比值标准检测睾酮未呈阳性。
