Mikkola Kaija, Kushnerenko Elena, Partanen Eino, Serenius-Sirve Silve, Leipälä Jaana, Huotilainen Minna, Fellman Vineta
Hospital for Children and Adolescents, Helsinki University Central Hospital, University of Helsinki, Tukholmankatu 8 A 5 krs, Helsinki, Finland.
Clin Neurophysiol. 2007 Jul;118(7):1494-502. doi: 10.1016/j.clinph.2007.04.012. Epub 2007 May 25.
In our previous study, auditory event-related potentials (AERPs) in preterm 1-year-old children had a positive deflection at 150-350 ms that correlated positively with their 2-year neurodevelopmental outcome. In a study of the same subjects at age 5, our aim was to assess AERPs and their relationship to neuropsychological test results.
Preterm small (SGA, n=13), appropriate for gestational age (AGA, n=15), and control (n=13) children were assessed with an Easy paradigm presenting a large frequency change accompanied with occasional novel sounds, and a Challenging paradigm presenting small frequency and duration changes with a rapid rate. The preterm children underwent neurocognitive tests.
Easy paradigm. The P1 response to frequency deviant was smaller and MMN larger in the preterm than in the control children. Challenging paradigm. The P1 response to standard, frequency, and duration deviants was smaller in the preterm than in the control children. The N2 response to frequency deviant was larger in the preterm than in the control children. AGA and SGA children had similar AERPs. The P1, N2, and MMN amplitudes correlated with verbal IQ and NEPSY language subtests.
Small P1 response(s) appears to be typical for preterm children.
Small P1 response in preterm children may suggest altered primary auditory processing.
在我们之前的研究中，1岁早产儿童的听觉事件相关电位（AERP）在150 - 350毫秒时有一个正向偏转，这与他们2岁时的神经发育结果呈正相关。在一项针对相同受试者5岁时的研究中，我们的目的是评估AERP及其与神经心理测试结果的关系。
对早产小样儿（SGA，n = 13）、适于胎龄儿（AGA，n = 15）和对照组儿童（n = 13）进行评估，采用简易范式呈现大频率变化并伴有偶尔的新声音，以及挑战性范式呈现小频率和持续时间变化且速率较快。对早产儿童进行神经认知测试。
简易范式。与对照组儿童相比，早产儿童对频率偏差的P1反应较小，失匹配负波（MMN）较大。挑战性范式。与对照组儿童相比，早产儿童对标准、频率和持续时间偏差的P1反应较小。与对照组儿童相比，早产儿童对频率偏差的N2反应较大。AGA和SGA儿童的AERP相似。P1、N2和MMN波幅与言语智商和NEPSY语言子测试相关。
较小的P1反应似乎是早产儿童的典型特征。
早产儿童较小的P1反应可能提示初级听觉处理改变。
