Akhlaghpoor Shahram, Shabestari Abbas Arjmand, Moghdam Mohsen Shojaei
Spiral CT Department, Noor Medical Imaging Center, Tehran, Iran.
Pediatr Int. 2007 Jun;49(3):387-91. doi: 10.1111/j.1442-200X.2007.02372.x.
The aim of this study was to determine the effectiveness of reduced new dose in rectal sedation by thiopental sodium for computed tomography (CT) diagnostic imaging.
A total of 90 children (mean age, 24.21 month +/- 13.63 [standard deviation]) underwent spiral CT study after rectal administration of thiopental sodium injection solution. The new dose ranged from 15 to 25 mg/kg with a total dose of 350 mg. The percentage of success and adverse reaction were evaluated.
Sedation was successful in 98% of infants and children with an average time of 8.04 min +/- 6.87 (standard deviation). One of the cases found desaturation, two experienced vomiting, 14 found rectal defecation, and two experienced hyperactivity. No prolonged sedation was observed.
Rectal administration of thiopental sodium for pediatric CT imaging is safe and effective even for hyperextend position by new reduced dose of the drug. This procedure could be easily done in the CT department under supervision of the radiologist.
本研究的目的是确定硫喷妥钠新的降低剂量用于计算机断层扫描（CT）诊断成像时直肠镇静的有效性。
共有90名儿童（平均年龄24.21个月±13.63[标准差]）在直肠给予硫喷妥钠注射液后接受螺旋CT检查。新剂量范围为15至25mg/kg，总剂量为350mg。评估成功百分比和不良反应。
98%的婴幼儿镇静成功，平均时间为8.04分钟±6.87（标准差）。其中1例出现血氧饱和度降低，2例出现呕吐，14例出现直肠排便，2例出现多动。未观察到镇静时间延长。
即使采用新的降低剂量的药物，直肠给予硫喷妥钠用于儿科CT成像也是安全有效的，即使是在过伸位。该操作可在放射科医生的监督下在CT室轻松完成。
