Atalay Yunus O, Leman Tomak, Tobias Joseph Drew
Department of Radiology, Outpatient Anaesthesia Service, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Department of Biostatistics and Medical Informatics, Ondokuz Mayis University, Samsun, Turkey.
Saudi J Anaesth. 2017 Apr-Jun;11(2):185-189. doi: 10.4103/1658-354X.203086.
Although the administration of rectal thiopental for sedation during magnetic resonance imaging (MRI) has been well described, there are limited data regarding its intravenous (IV) use in this clinical scenario. The aim of this study was to investigate the efficiency of IV thiopental for sedation during MRI in the pediatric population.
A retrospective review was conducted over a 12-month period of pediatric patients who received IV thiopental for sedation during MRI. Data collected included the procedure length, the induction dose, the time to sedation, recovery time, total sedation time, and adverse events. The parents were telephoned and questioned regarding any adverse effect after discharge and their satisfaction (yes = satisfied; no = not satisfied) regarding the sedation process.
A total of 300 (American Society of Anesthesiology I-II status) pediatric patients received IV thiopental for sedation during MRI. The average age of the patients was 4.7 ± 3 years. Thiopental was administered as an initial IV bolus dose of 3 mg/kg, followed by additional bolus doses of thiopental (1 mg/kg) as needed to achieve a Ramsay sedation score of 4. The average procedure length was 20.7 ± 11.9 min. The average total dose of thiopental during the procedure was 5.6 ± 0.9 mg/kg. Patients recovered in an average time of 11 ± 5.6 min after a total sedation time of 31.7 ± 14.2 min. None of the patients had oxygen desaturation, adverse effects before or after discharge, and no patient required unplanned hospital admission. All parents were satisfied with the sedation process.
IV thiopental is an effective, safe, and inexpensive medication for the sedation of children undergoing MRI.
尽管在磁共振成像（MRI）期间直肠给予硫喷妥钠用于镇静已得到充分描述，但关于其在此临床场景中静脉注射（IV）使用的数据有限。本研究的目的是调查静脉注射硫喷妥钠在儿科人群MRI检查期间用于镇静的有效性。
对在12个月期间接受静脉注射硫喷妥钠进行MRI镇静的儿科患者进行回顾性研究。收集的数据包括检查时长、诱导剂量、镇静起效时间、恢复时间、总镇静时间和不良事件。给家长打电话询问出院后有无任何不良反应以及他们对镇静过程的满意度（是 = 满意；否 = 不满意）。
共有300例（美国麻醉医师协会I-II级状态）儿科患者在MRI检查期间接受静脉注射硫喷妥钠镇静。患者的平均年龄为4.7±3岁。硫喷妥钠以3mg/kg的初始静脉推注剂量给药，随后根据需要追加硫喷妥钠推注剂量（1mg/kg）以达到Ramsay镇静评分4分。平均检查时长为20.7±11.9分钟。检查期间硫喷妥钠的平均总剂量为5.6±0.9mg/kg。患者在总镇静时间为31.7±14.2分钟后平均11±5.6分钟恢复。所有患者均未出现氧饱和度下降、出院前后的不良反应，也没有患者需要非计划住院。所有家长对镇静过程均满意。
静脉注射硫喷妥钠是用于接受MRI检查的儿童镇静的一种有效、安全且廉价的药物。
