Glasier C M, Stark J E, Brown R, James C A, Allison J W
Department of Radiology, Arkansas Children's Hospital, Little Rock 72202.
AJNR Am J Neuroradiol. 1995 Jan;16(1):111-4.
To determine the efficacy and safety of rectal thiopental sodium as a sedation agent for pediatric imaging.
Four hundred sixty-two infants and children were sedated with rectal thiopental sodium for MR, CT, or nuclear imaging in 1992 and 1993. Patients received screening histories and physical examinations before sedation, and parents gave informed consent. Sedated patients were monitored by pulse oximetry and direct observation. Twenty-four-hour telephone follow-up to assess delayed side effects was performed successfully in 325 patients.
Examinations were successfully completed in 96% of patients. The average time from drug administration to sedation was 12.2 minutes. The average time from sedation to discharge from radiology was 71.1 minutes. Eleven percent of patients had desaturation below the pulse oximetric baseline easily treated with oxygen and head positioning. Twenty-four-hour telephone follow-up in 325 patients revealed a 34% incidence of minor rectal irritation and diarrhea, sleepiness, nausea and vomiting, or ataxia.
Rectal thiopental sodium is a safe and effective drug for pediatric sedation.
确定直肠注射硫喷妥钠作为儿科成像镇静剂的有效性和安全性。
1992年和1993年，462名婴儿和儿童接受了直肠注射硫喷妥钠以进行磁共振成像（MR）、计算机断层扫描（CT）或核成像检查。患者在镇静前接受了病史筛查和体格检查，家长签署了知情同意书。对镇静患者进行脉搏血氧饱和度监测和直接观察。325名患者成功接受了24小时电话随访以评估延迟出现的副作用。
96%的患者检查成功完成。从给药到镇静的平均时间为12.2分钟。从镇静到离开放射科的平均时间为71.1分钟。11%的患者出现脉搏血氧饱和度低于基线水平的情况，通过吸氧和调整头部位置可轻松治疗。对325名患者进行的24小时电话随访显示，轻微直肠刺激和腹泻、嗜睡、恶心和呕吐或共济失调的发生率为34%。
直肠注射硫喷妥钠是一种用于儿科镇静的安全有效的药物。
