Alp H, Güler I, Orbak Z, Karakelleoğlu C, Tan H, Eren S
Department of Pediatrics, Atatürk University Faculty of Medicine, Erzurum, Turkey.
Pediatr Int. 1999 Oct;41(5):538-41. doi: 10.1046/j.1442-200x.1999.01124.x.
We evaluated the clinical safety, effectiveness, efficiency and potential side effects of rectally administered thiopental in 30 children undergoing computed tomography (CT) and magnetic resonance imaging (MRI).
The doses of thiopental used were 50 mg/kg for infants under 6 months of age, 35 mg/kg for infants between 6 and 12 months of age and 25 mg/kg for older children. After administration of the sedative, oxygen saturation was continuously monitored and vital signs were recorded every 20 min during the imaging procedure and then every 20 min until discharge.
Successful sedation and adequate imaging were obtained in 29 of 30 (96.7%) patients. Respiratory depression was not observed in any patient. However, oxygen saturation dropped below 90% transiently (to 88%) in three patients (10.0%) and this was immediately corrected by repositioning the child's neck to open the upper airway. All successfully sedated patients were asleep within 15 min (mean +/- SD 7.3 +/- 2.7 min) and sedation was sufficient for at least 30 min. Prolonged sedation was observed in two patients.
We believe that rectal thiopental is a safe, effective and efficient form of sedation for pediatric imaging.
我们评估了30例接受计算机断层扫描（CT）和磁共振成像（MRI）检查的儿童经直肠给予硫喷妥钠的临床安全性、有效性、效率及潜在副作用。
6个月以下婴儿硫喷妥钠的使用剂量为50mg/kg，6至12个月婴儿为35mg/kg，年龄较大儿童为25mg/kg。给予镇静剂后，持续监测血氧饱和度，并在成像过程中每20分钟记录一次生命体征，之后每20分钟记录一次直至出院。
30例患者中有29例（96.7%）成功镇静并获得了足够的成像。未观察到任何患者出现呼吸抑制。然而，3例患者（10.0%）的血氧饱和度短暂降至90%以下（至88%），通过重新调整患儿颈部位置以开放上呼吸道，这一情况立即得到纠正。所有成功镇静的患者在15分钟内入睡（平均±标准差7.3±2.7分钟），镇静效果至少持续30分钟。观察到2例患者镇静时间延长。
我们认为直肠给予硫喷妥钠是一种用于儿科成像的安全、有效且高效的镇静方式。
