Ibrahim Enas G, Abdel Wahed Wafaa Y, Eid Hanaa M, Deeb Wessam S
1Microbiology Department, Faculty of Medicine, Fayoum University, Faiyum, Egypt.
2Public Health & Community Medicine Department, Faculty of Medicine, Fayoum University, Faiyum, 63514 Egypt.
J Egypt Public Health Assoc. 2019;94(1):2. doi: 10.1186/s42506-018-0002-5. Epub 2019 Jan 7.
Chickenpox infection acquired during pregnancy is a serious condition. There may be congenital malformations and neonatal varicella syndrome with significant morbidity and mortality. Egypt has no routine varicella-zoster vaccination program.
To assess the immune status against varicella-zoster virus (VZV) antibodies among a group of pregnant women and to study the relationship between VZV seroprevalence and some sociodemographic characteristics.
A descriptive cross-sectional study was conducted on a group of pregnant women ( = 333) attending antenatal care (ANC) clinic at Fayoum University Hospital. Serologic testing for VZV was performed using ELISA through the years 2016-2017.
VZV seroprevalence was detected in 294 (88.3%) of the 333 recruited pregnant women. Older age > 25 years old was significantly associated with low percent of VZV-negative antibodies (6.7% in versus 17.4% in younger age, OR (95%CI) 0.34 (0.17-0.70)), also having more than one child was significantly associated with a low percent of VZV-negative antibodies (8.2% versus 16.1% among participants with no children or having one child, OR 0.34 (0.17-0.70)).
Despite the absence of a routine VZV vaccination program in Egypt, VZV immunity was high among pregnant women, but less than that reported in many developed countries. We recommend targeted vaccination for women in the reproductive age especially young and primipara.
Ethical Committee Registration number R67 session 42: date 12/11/2017(retrospectively registered).
孕期感染水痘是一种严重情况。可能会出现先天性畸形和新生儿水痘综合征，具有较高的发病率和死亡率。埃及没有常规的水痘 - 带状疱疹疫苗接种计划。
评估一组孕妇针对水痘 - 带状疱疹病毒（VZV）抗体的免疫状态，并研究VZV血清阳性率与一些社会人口学特征之间的关系。
对法尤姆大学医院产前保健（ANC）诊所的一组孕妇（n = 333）进行了描述性横断面研究。在2016 - 2017年期间使用ELISA进行VZV血清学检测。
在333名招募的孕妇中，294名（88.3%）检测到VZV血清阳性。年龄大于25岁与VZV阴性抗体比例低显著相关（年龄较大者为6.7%，较年轻者为17.4%，OR（95%CI）0.34（0.17 - 0.70）），此外，有多个孩子也与VZV阴性抗体比例低显著相关（有多个孩子者为8.2%，无孩子或只有一个孩子的参与者中为16.1%，OR 0.34（0.17 - 0.70））。
尽管埃及没有常规的VZV疫苗接种计划，但孕妇中VZV免疫力较高，但低于许多发达国家报告的水平。我们建议对育龄妇女，尤其是年轻妇女和初产妇进行针对性接种。
伦理委员会注册号R67第42届会议：日期2017年11月12日（追溯注册）
