Hwang Stephen W, Cheung Angela M, Moineddin Rahim, Bell Chaim M
Centre for Research on Inner City Health, the Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Canada.
BMC Public Health. 2007 May 29;7:93. doi: 10.1186/1471-2458-7-93.
Extraordinary infection control measures limited access to medical care in the Greater Toronto Area during the 2003 Severe Acute Respiratory Syndrome (SARS) outbreak. The objective of this study was to determine if the period of these infection control measures was associated with changes in overall population mortality due to causes other than SARS.
Observational study of death registry data, using Poisson regression and interrupted time-series analysis to examine all-cause mortality rates (excluding deaths due to SARS) before, during, and after the SARS outbreak. The population of Ontario was grouped into the Greater Toronto Area (N = 2.9 million) and the rest of Ontario (N = 9.3 million) based upon the level of restrictions on delivery of clinical services during the SARS outbreak.
There was no significant change in mortality in the Greater Toronto Area before, during, and after the period of the SARS outbreak in 2003 compared to the corresponding time periods in 2002 and 2001. The rate ratio for all-cause mortality during the SARS outbreak was 0.99 [95% Confidence Interval (CI) 0.93-1.06] compared to 2002 and 0.96 [95% CI 0.90-1.03] compared to 2001. An interrupted time series analysis found no significant change in mortality rates in the Greater Toronto Area associated with the period of the SARS outbreak.
Limitations on access to medical services during the 2003 SARS outbreak in Toronto had no observable impact on short-term population mortality. Effects on morbidity and long-term mortality were not assessed. Efforts to contain future infectious disease outbreaks due to influenza or other agents must consider effects on access to essential health care services.
在2003年严重急性呼吸综合征(SARS)疫情爆发期间,多伦多地区采取了严格的感染控制措施,这限制了人们获得医疗服务的机会。本研究的目的是确定这些感染控制措施实施期间是否与除SARS之外的其他原因导致的总体人群死亡率变化有关。
对死亡登记数据进行观察性研究,使用泊松回归和中断时间序列分析来检查SARS疫情爆发前、期间和之后的全因死亡率(不包括因SARS导致的死亡)。根据SARS疫情爆发期间临床服务提供的限制程度,安大略省的人口被分为大多伦多地区(N = 290万)和安大略省其他地区(N = 930万)。
与2002年和2001年的相应时间段相比,2003年SARS疫情爆发期间、之前和之后,大多伦多地区的死亡率没有显著变化。与2002年相比,SARS疫情爆发期间全因死亡率的率比为0.99 [95%置信区间(CI)0.93 - 1.06],与2001年相比为0.96 [95% CI 0.90 - 1.03]。中断时间序列分析发现,大多伦多地区的死亡率与SARS疫情爆发期间没有显著变化。
2003年多伦多SARS疫情爆发期间对医疗服务获取的限制对短期人群死亡率没有明显影响。未评估对发病率和长期死亡率的影响。在控制未来因流感或其他病原体引起的传染病爆发时,必须考虑对基本医疗服务获取的影响。