Mossman Brooke T, Borm Paul J, Castranova Vincent, Costa Daniel L, Donaldson Kenneth, Kleeberger Steven R
Department of Pathology, University of Vermont, 89 Beaumont Avenue, HSRF 218, Burlington, VT 05405, USA.
Part Fibre Toxicol. 2007 May 30;4:4. doi: 10.1186/1743-8977-4-4.
A symposium on the mechanisms of action of inhaled airborne particulate matter (PM), pathogenic particles and fibers such as silica and asbestos, and nanomaterials, defined as synthetic particles or fibers less than 100 nm in diameter, was held on October 27 and 28, 2005, at the Environmental Protection Agency (EPA) Conference Center in Research Triangle Park, North Carolina. The meeting was the eighth in a series of transatlantic conferences first held in Penarth, Wales, at the Medical Research Council Pneumoconiosis Unit (1979), that have fostered long-standing collaborations between researchers in the fields of mineralogy, cell and molecular biology, pathology, toxicology, and environmental/occupational health.
The goal of this meeting, which was largely supported by a conference grant from the NHLBI, was to assemble a group of clinical and basic research scientists who presented and discussed new data on the mechanistic effects of inhaled particulates on the onset and development of morbidity and mortality in the lung and cardiovascular system. Another outcome of the meeting was the elucidation of a number of host susceptibility factors implicated in adverse health effects associated with inhaled pathogenic particulates.
New models and data presented supported the paradigm that both genetic and environmental (and occupational) factors affect disease outcomes from inhaled particulates as well as cardiopulmonary responses. These future studies are encouraged to allow the design of appropriate strategies for prevention and treatment of particulate-associated morbidity and mortality, especially in susceptible populations.
2005年10月27日至28日，一场关于吸入性空气颗粒物（PM）、致病颗粒及纤维（如二氧化硅和石棉）以及纳米材料（定义为直径小于100纳米的合成颗粒或纤维）作用机制的研讨会在北卡罗来纳州三角研究园的环境保护局（EPA）会议中心举行。此次会议是一系列跨大西洋会议中的第八次会议，该系列会议首次于1979年在威尔士的佩纳斯的医学研究理事会尘肺病研究室召开，促进了矿物学、细胞与分子生物学、病理学、毒理学以及环境/职业健康领域研究人员之间的长期合作。
本次会议的目标在很大程度上得到了美国国立心肺血液研究所（NHLBI）会议资助的支持，即召集一群临床和基础研究科学家，他们展示并讨论了关于吸入颗粒物对肺部和心血管系统发病及死亡的起始和发展的机制性影响的新数据。会议的另一个成果是阐明了一些与吸入致病颗粒物相关的不良健康影响所涉及的宿主易感性因素。
会上展示的新模型和数据支持了这样一种范式，即遗传和环境（以及职业）因素都会影响吸入颗粒物导致的疾病结果以及心肺反应。鼓励开展这些未来研究，以便设计出预防和治疗与颗粒物相关的发病和死亡的适当策略，尤其是在易感人群中。
