Wennberg Maria, Bergdahl Ingvar A, Stegmayr Birgitta, Hallmans Göran, Lundh Thomas, Skerfving Staffan, Strömberg Ulf, Vessby Bengt, Jansson Jan-Håkan
Department of Medicine, Skellefteå Hospital, Sweden.
Br J Nutr. 2007 Nov;98(5):1038-45. doi: 10.1017/S0007114507756519. Epub 2007 May 31.
Results of previous studies on fish intake and stroke risk have been inconclusive. Different stroke types have often not been separated. Our aim was to elucidate whether intake of fish, Hg or the sum of proportions of fatty acids EPA (20 : 5n-3) and DHA (22 : 6n-3) influence the risk of haemorrhagic or ischaemic stroke. Within a population-based cohort from a community intervention programme, 369 stroke cases and 738 matched controls were identified and included in the present nested case-control study. Information on fish intake had been recorded at recruitment, i.e. before diagnosis. Hg levels were determined in erythrocyte membranes, also collected at recruitment, and the relative content of fatty acids was measured in erythrocyte membranes or plasma phospholipids. The results showed that in women there was a non-significant decrease in stroke risk with increasing fish intake (OR 0.90 (95 % CI 0.73, 1.11) per meal per week). The risk in women differed significantly (P = 0.03) from that in men, in whom the OR for stroke rose with increasing fish intake (OR 1.24 (95 % CI 1.01, 1.51) per meal per week). The corresponding risk in men for Hg was 0.99 (95 % CI 0.93, 1.06), and for the sum of proportions of EPA and DHA 1.08 (95 % CI 0.92, 1.28). We conclude that the relationship between stroke risk and fish intake seems to be different in men and women. Increased levels of EPA and DHA do not decrease the risk for stroke and there is no association between stroke risk and Hg at these low levels.
先前关于鱼类摄入与中风风险的研究结果尚无定论。不同类型的中风往往未被区分开来。我们的目的是阐明鱼类、汞的摄入量或脂肪酸二十碳五烯酸（20 : 5n-3）和二十二碳六烯酸（22 : 6n-3）的比例总和是否会影响出血性或缺血性中风的风险。在一项社区干预项目的基于人群的队列研究中，识别出369例中风病例和738例匹配对照，并纳入本巢式病例对照研究。鱼类摄入量信息在招募时即诊断前进行了记录。汞水平在招募时采集的红细胞膜中测定，脂肪酸的相对含量在红细胞膜或血浆磷脂中进行测量。结果显示，在女性中，随着鱼类摄入量增加，中风风险有不显著的降低（每周每餐的比值比为0.90（95%置信区间为0.73，1.11））。女性的风险与男性有显著差异（P = 0.03），在男性中，中风的比值比随着鱼类摄入量增加而升高（每周每餐的比值比为1.24（95%置信区间为1.01，1.51））。男性中汞的相应风险为0.99（95%置信区间为0.93，1.06），二十碳五烯酸和二十二碳六烯酸比例总和的风险为1.08（95%置信区间为0.92，1.28）。我们得出结论，中风风险与鱼类摄入量之间的关系在男性和女性中似乎有所不同。二十碳五烯酸和二十二碳六烯酸水平升高并不会降低中风风险，在这些低水平下中风风险与汞之间也没有关联。
