LaRowe Steven D, Saladin Michael E, Carpenter Matthew J, Upadhyaya Himanshu P
Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina (MUSC), Charleston SC, 29425, USA.
Addict Behav. 2007 Dec;32(12):2888-99. doi: 10.1016/j.addbeh.2007.04.025. Epub 2007 May 3.
The present study investigated whether reactivity to nicotine-related cues would attenuate across four experimental sessions held 1 week apart. Participants were nineteen non-treatment seeking, nicotine-dependent males. Cue reactivity sessions were performed in an outpatient research center using in vivo cues consisting of standardized smoking-related paraphernalia (e.g., cigarettes) and neutral comparison paraphernalia (e.g., pencils). Craving ratings were collected before and after both cue presentations while physiological measures (heart rate, skin conductance) were collected before and during the cue presentations. Although craving levels decreased across sessions, smoking-related cues consistently evoked significantly greater increases in craving relative to neutral cues over all four experimental sessions. Skin conductance was higher in response to smoking cues, though this effect was not as robust as that observed for craving. Results suggest that, under the described experimental parameters, craving can be reliably elicited over repeated cue reactivity sessions.
本研究调查了对尼古丁相关线索的反应性在相隔1周进行的四个实验环节中是否会减弱。参与者为19名未寻求治疗的尼古丁依赖男性。线索反应性环节在门诊研究中心进行，使用由标准化吸烟相关用具（如香烟）和中性对照用具（如铅笔）组成的真实线索。在两种线索呈现之前和之后收集渴望评分，同时在线索呈现之前和期间收集生理指标（心率、皮肤电导率）。尽管各环节中渴望水平有所下降，但在所有四个实验环节中，与吸烟相关的线索相对于中性线索始终能显著引发更大的渴望增加。对吸烟线索的反应中皮肤电导率更高，不过这种效应不如在渴望方面观察到的那么强烈。结果表明，在所描述的实验参数下，在重复的线索反应性环节中可以可靠地引发渴望。
