Heukamp L C, Knoblich A, Rausch E, Friedrichs N, Schildhaus H U, Kahl P, Tismer R, Schneider B, Büttner R, Houshdaran F
Institute of Pathology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
Pathol Res Pract. 2007;203(6):473-7. doi: 10.1016/j.prp.2007.03.005. Epub 2007 May 29.
Extraskeletal osteosarcoma (EOS) is a highly aggressive and exceedingly rare mesenchymal tumor. Due to the rare nature of the disease, the diagnosis can be difficult and is often confirmed only after diagnostic laparotomy and histopathology. We describe the clinical history, radiologic and histomorphologic presentation, and clinical management of a 61-year-old patient who presented with abdominal pain. Abdominal ultrasound and computerized tomography (CT) scan revealed a calcified intra-abdominal mass. Following an explorative laparotomy, histology showed a large extraosseous osteosarcoma of the small bowel mesentery. Therapy according to the Cooperative Sarcoma Study-96 (COSS-96) was commenced. Diagnosis, management, and outcome in the context of the current literature are discussed. To our knowledge, this is the first description of an extraosseous osteosarcomas in the small bowel mesentery in the literature.
骨外骨肉瘤（EOS）是一种侵袭性很强且极为罕见的间叶性肿瘤。由于该疾病的罕见性，诊断可能会很困难，通常只有在诊断性剖腹手术和组织病理学检查后才能确诊。我们描述了一名61岁出现腹痛患者的临床病史、放射学和组织形态学表现以及临床治疗情况。腹部超声和计算机断层扫描（CT）显示腹内有一钙化肿块。在进行探查性剖腹手术后，组织学检查显示为小肠系膜的一个巨大骨外骨肉瘤。随后开始按照肉瘤协作研究-96（COSS-96）方案进行治疗。本文结合当前文献讨论了该病例的诊断、治疗及预后情况。据我们所知，这是文献中首次对小肠系膜骨外骨肉瘤的描述。
