Pearson S D, Ackerman R A, Seagrave R C
Iowa State University, Ames 50011.
J Theor Biol. 1991 Sep 21;152(2):223-40. doi: 10.1016/s0022-5193(05)80454-0.
A quantitative phenomenological model to describe the relationships between biomass growth rate, oxygen consumption, and heat production in developing embryos has been developed and tested using a wide range of experimental data. The model employs generalized material and energy balances, principles of enzyme kinetics, and an overall metabolic model scheme based on known biochemical principles. The phosphorylation concentration ratio of ATP and ADP occurs naturally and becomes a significant parameter in the analysis. The model is applied to the growth of Escherichia coli, Oryzias latipes, chick spinal cord, and whole chicken eggs. Excellent agreement between the model and the experimental data is obtained. In a succeeding paper (Part II) environmental effects and growth efficiency are discussed.
已开发出一种定量现象学模型，用于描述发育中胚胎的生物量生长速率、氧气消耗和热量产生之间的关系，并使用大量实验数据进行了测试。该模型采用广义物质和能量平衡、酶动力学原理以及基于已知生化原理的整体代谢模型方案。ATP和ADP的磷酸化浓度比自然发生，并成为分析中的一个重要参数。该模型应用于大肠杆菌、青鳉、鸡脊髓和整个鸡蛋的生长。模型与实验数据之间取得了极好的一致性。在后续论文（第二部分）中讨论了环境影响和生长效率。
