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CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP.系统发育树的置信区间：一种使用自展法的方法。
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2
Emergence of recent echovirus 30 lineages is marked by serial genetic recombination events.近期肠道病毒30型谱系的出现以一系列基因重组事件为特征。
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3
Recombination and selection in the evolution of picornaviruses and other Mammalian positive-stranded RNA viruses.小核糖核酸病毒及其他哺乳动物正链RNA病毒进化中的重组与选择
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Phylogenetic evidence for inter-typic recombination in the emergence of human enterovirus 71 subgenotypes.人类肠道病毒71型亚型出现过程中跨型重组的系统发育证据。
BMC Microbiol. 2006 Aug 30;6:74. doi: 10.1186/1471-2180-6-74.
5
Evolution of 2B and 2C genomic parts of species B Coxsackie viruses. Phylogenetic study and comparison with other regions.B组柯萨奇病毒2B和2C基因组部分的进化。系统发育研究及与其他区域的比较。
Virus Genes. 2006 Jun;32(3):249-59. doi: 10.1007/s11262-005-6909-x.
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Molecular characterization of wild-type polioviruses isolated in Greece during the 1996 outbreak in Albania.1996年阿尔巴尼亚疫情期间在希腊分离出的野生型脊髓灰质炎病毒的分子特征
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Frequency and dynamics of recombination within different species of human enteroviruses.人类肠道病毒不同种属间重组的频率与动态变化
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Recombination in circulating Human enterovirus B: independent evolution of structural and non-structural genome regions.人肠道病毒B型流行株的重组：结构基因组区域与非结构基因组区域的独立进化
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9
Intratypic recombination among lineages of type 1 vaccine-derived poliovirus emerging during chronic infection of an immunodeficient patient.在一名免疫缺陷患者慢性感染期间出现的1型疫苗衍生脊髓灰质炎病毒谱系间的型内重组。
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Role of recombination in evolution of enteroviruses.重组在肠道病毒进化中的作用。
Rev Med Virol. 2005 May-Jun;15(3):157-67. doi: 10.1002/rmv.457.

衣壳基因组区域内的自然重组事件导致了一种人肠道病毒B的嵌合毒株。

Natural recombination event within the capsid genomic region leading to a chimeric strain of human enterovirus B.

作者信息

Bouslama Lamjed, Nasri Dorsaf, Chollet Lionel, Belguith Khaoula, Bourlet Thomas, Aouni Mahjoub, Pozzetto Bruno, Pillet Sylvie

机构信息

Laboratory of Transmissible Diseases and Biologically Active Substances, Faculty of Pharmacy, Monastir, Tunisia.

出版信息

J Virol. 2007 Sep;81(17):8944-52. doi: 10.1128/JVI.00180-07. Epub 2007 May 30.

DOI:10.1128/JVI.00180-07
PMID:17537864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1951430/
Abstract

Recombination between two strains is a known phenomenon for enteroviruses replicating within a single cell. We describe a recombinant strain recovered from human stools, typed as coxsackievirus B4 (CV-B4) and CV-B3 after partial sequencing of the VP1 and VP2 coding regions, respectively. The strain was neutralized by a polyclonal CV-B3-specific antiserum but not by a CV-B4-specific antiserum. The nucleotide sequence analysis of the whole structural genomic region showed the occurrence of a recombination event at position 1950 within the VP3 capsid gene, in a region coding for the 2b antigenic site previously described for CV-B3. This observation evidences for the first time the occurrence of an interserotypic recombination within the VP2-VP3-VP1 capsid region between two nonpoliovirus enterovirus strains. The neutralization pattern suggests that the major antigenic site is located within the VP2 protein.

摘要

对于在单个细胞内复制的肠道病毒而言，两个毒株之间发生重组是一种已知现象。我们描述了一株从人类粪便中分离出的重组毒株，在分别对VP1和VP2编码区进行部分测序后，该毒株被鉴定为柯萨奇病毒B4（CV - B4）和CV - B3。该毒株能被CV - B3特异性多克隆抗血清中和，但不能被CV - B4特异性抗血清中和。对整个结构基因组区域的核苷酸序列分析表明，在VP3衣壳基因内第1950位发生了重组事件，该区域编码先前描述的CV - B3的2b抗原位点。这一观察首次证明了两种非脊髓灰质炎肠道病毒毒株在VP2 - VP3 - VP1衣壳区域内发生了血清型间重组。中和模式表明主要抗原位点位于VP2蛋白内。