Shrivastava Sadhana, Jadon Anjana, Shukla Sangeeta
J Toxicol Sci. 2007 May;32(2):185-92. doi: 10.2131/jts.32.185.
In the present study an attempt has been made to evaluate the effect of Tiron along with Zinc, Selenium and Vitamin E against vanadium intoxication in female albino rats. Toxicant caused significant increase in the activities of serum transaminases, serum alkaline phosphatase and lactate dehydrogenase. Significant decrease was observed in blood sugar, serum albumin and triglyceride levels whereas serum proteins, cholesterol and urea levels increased significantly during toxicity (p </= 0.001). Hepatic lipid peroxidation increased significantly, whereas significant depletion was observed in reduced glutathione after vanadium administration. The activity of glucose-6-phosphatase in the liver was also inhibited significantly after vanadium administration. A significant rise was observed in glycogen content of liver and kidney after toxicant exposure. Activities of alkaline phosphatase, adenosine triphosphatase and succinic dehydrogenase were inhibited significantly on the contrary activity of acid phosphatase elevated in kidney. Histopathological examination of the liver and kidney using light and ultramicroscopic study also substantiated the above findings. It was found that therapy with Tiron was effective but significant recovery in all the parameters was found with Tiron + Se followed by Tiron+ VitE and Tiron +Zn.
在本研究中，已尝试评估替诺（Tiron）与锌、硒和维生素E联合使用对雌性白化大鼠钒中毒的影响。毒物导致血清转氨酶、血清碱性磷酸酶和乳酸脱氢酶的活性显著增加。在毒性作用期间，血糖、血清白蛋白和甘油三酯水平显著降低，而血清蛋白、胆固醇和尿素水平显著升高（p≤0.001）。钒给药后，肝脏脂质过氧化显著增加，而还原型谷胱甘肽显著减少。钒给药后，肝脏中葡萄糖-6-磷酸酶的活性也受到显著抑制。毒物暴露后，肝脏和肾脏的糖原含量显著升高。相反，肾脏中碱性磷酸酶、三磷酸腺苷酶和琥珀酸脱氢酶的活性受到显著抑制，而酸性磷酸酶的活性升高。使用光学显微镜和超微显微镜对肝脏和肾脏进行组织病理学检查也证实了上述发现。发现用替诺治疗是有效的，但在所有参数中，替诺+硒治疗后有显著恢复，其次是替诺+维生素E和替诺+锌。
