Pan Weihong, Kastin Abba J
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, United States.
Peptides. 2007 Jun;28(6):1317-30. doi: 10.1016/j.peptides.2007.04.023. Epub 2007 May 6.
Just as the blood-brain barrier (BBB) is not a static barrier, the adipocytes are not inert storage depots. Adipokines are peptides or polypeptides produced by white adipose tissue; they play important roles in normal physiology as well as in the metabolic syndrome. Adipokines secreted into the circulation can interact with the BBB and exert potent CNS effects. The specific transport systems for two important adipokines, leptin and tumor necrosis factor alpha, have been characterized during the past decade. By contrast, transforming growth factor beta-1 and adiponectin do not show specific permeation across the BBB, but modulate endothelial functions. Still others, like interleukin-6, may reach the brain but are rapidly degraded. This review summarizes current knowledge and recent findings of the rapidly growing family of adipokines and their interactions with the BBB.
正如血脑屏障（BBB）并非静态屏障一样，脂肪细胞也不是惰性储存库。脂肪因子是由白色脂肪组织产生的肽或多肽；它们在正常生理以及代谢综合征中发挥重要作用。分泌到循环系统中的脂肪因子可与血脑屏障相互作用并发挥强大的中枢神经系统效应。在过去十年中，已经对两种重要脂肪因子——瘦素和肿瘤坏死因子α的特定转运系统进行了表征。相比之下，转化生长因子β-1和脂联素在血脑屏障中没有显示出特定的渗透，但可调节内皮功能。还有其他一些因子，如白细胞介素-6，可能会进入大脑，但会迅速降解。本综述总结了快速增长的脂肪因子家族的当前知识和最新发现，以及它们与血脑屏障的相互作用。
