Arnoldussen Ilse A C, Kiliaan Amanda J, Gustafson Deborah R
Department of Anatomy, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Geert Grooteplein Noord 21, 6525 EZ Nijmegen, The Netherlands.
Department of Neurology, State University of New York-Downstate Medical Center, 450 Clarkson Avenue, Box 1213, Brooklyn, NY11203, USA; UMS 011 Inserm Versailles Saint Quentin, France; Section for Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Sahlgrenska Academy at University of Gothenburg, Institute for Neuroscience and Physiology, NeuroPsychiatric Epidemiology Unit, Wallinsgatan 6, 431 41 Gothenburg, Sweden.
Eur Neuropsychopharmacol. 2014 Dec;24(12):1982-99. doi: 10.1016/j.euroneuro.2014.03.002. Epub 2014 Mar 20.
Obesity is a pandemic and a serious global health concern. Obesity is a risk factor for multiple conditions and contributes to multi-morbidities, resulting in increased health costs and millions of deaths each year. Obesity has been associated with changes in brain structure, cognitive deficits, dementia and Alzheimer׳s disease. Adipokines, defined as hormones, cytokines and peptides secreted by adipose tissue, may have more widespread influence and functionality in the brain than previously thought. In this review, six adipokines, and their actions in the obese and non-obese conditions will be discussed. Included are: plasminogen activator inhibitor-1 (PAI-1), interleukin-6 (IL-6), tumor necrosis factors alpha (TNF-α), angiotensinogen (AGT), adiponectin and leptin. Their functionality in the periphery, their ability to cross the blood brain barrier (BBB) and their influence on dementia processes within the brain will be discussed.
肥胖是一种流行病，也是一个严重的全球健康问题。肥胖是多种疾病的风险因素，会导致多种并发症，每年造成医疗成本增加和数百万人死亡。肥胖与脑结构变化、认知缺陷、痴呆症和阿尔茨海默病有关。脂肪因子被定义为由脂肪组织分泌的激素、细胞因子和肽，其在大脑中的影响和功能可能比以前认为的更为广泛。在这篇综述中，将讨论六种脂肪因子及其在肥胖和非肥胖状态下的作用。包括：纤溶酶原激活物抑制剂-1（PAI-1）、白细胞介素-6（IL-6）、肿瘤坏死因子α（TNF-α）、血管紧张素原（AGT）、脂联素和瘦素。将讨论它们在外周的功能、穿过血脑屏障（BBB）的能力以及对脑内痴呆进程的影响。
