Bar-Ilan A, Naveh N, Weissman C, Belkin M, Schwartz M
Maurice and Gabriela Goldschleger Eye Research Institute, Tel Aviv University, Sackler Faculty of Medicine, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Neuroscience. 1991;45(1):221-5. doi: 10.1016/0306-4522(91)90118-8.
Changes in arachidonic acid metabolism were studied in the optic nerve, the chorioretina, and in the vitreous following crush injury to the optic nerve of rats. Crush injury led to: (i) a 3.9-fold increase in optic nerve prostaglandin type E2 in vitro production which peaked on day 5 and was followed by a gradual decline, but was still significantly higher than baseline levels by day 12; (ii) a two-fold increase in the chorioretina prostaglandin type E2 in vitro production which peaked on day 1, and resumed baseline levels by day 3; (iii) a 3.5-fold increase in vitreous prostaglandin type E2 levels on day 1 which remained at 1.5-2 times higher than baseline levels for the rest of the study period (12 days). The findings indicate that the pattern of changes in prostaglandin type E2 production by the optic nerve (consisting mostly of white matter) is different from that described for injured brain tissues. The prolonged accumulation of vitreal prostaglandin type E2 in eyes with damaged optic nerve may lead to undesirable effects on the retina beyond those directly manifested in the retina by altered axonal flow in the injured optic nerve.
在大鼠视神经挤压伤后，研究了视神经、脉络膜视网膜和玻璃体中花生四烯酸代谢的变化。挤压伤导致：（i）视神经前列腺素E2体外生成增加3.9倍，在第5天达到峰值，随后逐渐下降，但到第12天仍显著高于基线水平；（ii）脉络膜视网膜前列腺素E2体外生成增加两倍，在第1天达到峰值，并在第3天恢复到基线水平；（iii）玻璃体前列腺素E2水平在第1天增加3.5倍，在研究期（12天）的其余时间保持比基线水平高1.5 - 2倍。这些发现表明，主要由白质组成的视神经中前列腺素E2生成的变化模式不同于受伤脑组织中所描述的模式。视神经受损的眼睛中玻璃体前列腺素E2的长期积累可能对视网膜产生不良影响，超出受伤视神经中轴突流改变直接在视网膜中表现出的影响。
