Naveh N, Weissman C
Maurice and Gabriela Goldschleger Eye Research Institute, Sheba Medical Center, Tel Hashomer, Israel.
Invest Ophthalmol Vis Sci. 1990 Jan;31(1):9-13.
The current study investigated the effect of steroid treatment of eyes subjected to a single retinal argon laser lesion on vitreal accumulation of both prostaglandin E2 (PGE2) and protein and their relationship with the amounts of PGE2 released from the retina-choroid. Laser exposure resulted in an elevation in the amounts of PGE2 released by the retina-choroid of laser-treated eyes: there was an initial peak on day 1, followed by a higher peak on day 7 (13.0 +/- 3.9 ng/mg protein and 32.9 +/- 4.9 ng/mg protein, respectively) after which levels progressively declined. Steroid treatment prevented the initial peak, but did not prevent the enhanced PGE2 amounts released during the second week. Thus, on day 7 the amounts released were lower by 32% than in the untreated group (21.0 +/- 8.6 ng/mg protein vs 32.9 +/- 4.9 ng/mg protein, P = 0.000); by day 14, however, peak values in the treated group were higher than in the untreated group (32.2 +/- 12.4 ng/mg protein and 10.6 +/- 4.5 ng/mg protein, respectively). In steroid-treated eyes, vitreal PGE2 concentration remained unchanged from baseline over a 2-week follow-up, whereas in the untreated laser group, levels peaked on day 7 to 10.7 +/- 3.6 ng/ml, exceeding baseline levels of 5.8 +/- 1.7 ng/ml (P = 0.0002). Laser exposure was also associated with a biphasic elevation in vitreal protein concentrations on days 3 and 14 (0.68 +/- 0.16 mg/ml and 0.79 +/- 0.13 mg/ml, respectively); these were significantly higher than the baseline value of 0.43 +/- 0.12 mg/ml (P = 0.03 and P = 0.004, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
本研究调查了对单眼视网膜氩激光损伤进行类固醇治疗，对玻璃体中前列腺素E2（PGE2）和蛋白质积聚的影响，以及它们与视网膜 - 脉络膜释放的PGE2量之间的关系。激光照射导致激光治疗眼的视网膜 - 脉络膜释放的PGE2量增加：第1天出现初始峰值，随后在第7天出现更高的峰值（分别为13.0±3.9 ng/mg蛋白质和32.9±4.9 ng/mg蛋白质），之后水平逐渐下降。类固醇治疗可防止初始峰值，但不能阻止第二周期间释放的PGE2量增加。因此，在第7天，释放量比未治疗组低32%（21.0±8.6 ng/mg蛋白质对32.9±4.9 ng/mg蛋白质，P = 0.000）；然而，到第14天，治疗组的峰值高于未治疗组（分别为32.2±12.4 ng/mg蛋白质和10.6±4.5 ng/mg蛋白质）。在接受类固醇治疗的眼中，玻璃体PGE2浓度在2周的随访中与基线相比保持不变，而在未治疗的激光组中，水平在第7天达到峰值，为10.7±3.6 ng/ml，超过基线水平5.8±1.7 ng/ml（P = 0.0002）。激光照射还与第3天和第14天玻璃体蛋白质浓度的双相升高有关（分别为0.68±0.16 mg/ml和0.79±0.13 mg/ml）；这些显著高于基线值0.43±0.12 mg/ml（分别为P = 0.03和P = 0.004）。（摘要截断于250字）
