Naveh N, Bartov E, Weissman C
Maurice and Gabriela Goldschleger Eye Institute, Tel Hashomer, Israel.
Graefes Arch Clin Exp Ophthalmol. 1991;229(2):178-81. doi: 10.1007/BF00170553.
Chorioretinal production of prostaglandin type E2 (PGE2) as well as changes in vitreal protein and PGE2 concentrations were studied following retinal irradiation with low-power laser energy that caused ophthalmoscopically invisible ("subthreshold") laser burns. This was compared with changes following ophthalmoscopically visible ("suprathreshold") laser burns. Our results demonstrate that with in eyes exposed to the lower-power levels, the enhancement in vitreal PGE2 concentration persisted for a longer period and was more pronounced than in eyes exposed to the suprathreshold levels (a 3-fold and a 2-fold increase above baseline values, respectively). Protein leakage into the vitreous was noted only in the suprathreshold group, indicating a blood-retinal barrier (BRB) disruption. The findings of persistent, excessive PGE2 vitreal levels with no protein leakage in the subthreshold group suggest a possible anti-inflammatory role for PGE2 following low-power laser exposure.
在用低功率激光能量进行视网膜照射后，研究了脉络膜视网膜中前列腺素E2（PGE2）的产生以及玻璃体内蛋白质和PGE2浓度的变化，这种照射会导致眼底镜下不可见（“阈下”）的激光灼伤。将此与眼底镜下可见（“阈上”）激光灼伤后的变化进行比较。我们的结果表明，在暴露于较低功率水平的眼睛中，玻璃体内PGE2浓度的升高持续时间更长，且比暴露于阈上水平的眼睛更明显（分别比基线值增加3倍和2倍）。仅在阈上组中观察到蛋白质渗漏到玻璃体中，这表明血视网膜屏障（BRB）被破坏。阈下组中玻璃体内PGE2水平持续过高且无蛋白质渗漏的结果表明，低功率激光照射后PGE2可能具有抗炎作用。
