Naveh N, Bar-Ilan A, Rosner M, Schwartz M, Weissman C, Belkin M
Maurice and Gabriela Goldschleger Eye Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel.
J Neurosci Res. 1990 Jul;26(3):386-9. doi: 10.1002/jnr.490260316.
Helium-neon low-energy laser (LEL) irradiation, known for its therapeutic effects in arthritis, wound healing, and muscular strain, was applied to eyes of rats that had sustained an optic nerve crush injury. Crush injury to the optic nerve resulted in a long-lasting in vitro elevation of prostaglandin E2 (PGE2) production (1.8-3.9-fold above control values during the 12 day study period). LEL irradiation per se had no effect in vitro on PGE2 production by the optic nerve; however, LEL irradiation of eyes with crushed optic nerve inhibited the enhanced production of PGE2 and leukotriene B4 in vitro by 55% and 75% during the late and immediate phase after trauma, respectively. Our findings of the suppressive effect of LEL irradiation on arachidonic acid metabolism are reminiscent of the actions of steroidal and nonsteroidal anti-inflammatory drugs, and might indicate, for the first time, the possible biochemical mechanisms associated with the clinical anti-inflammatory effects of LEL irradiation.
氦氖低能量激光（LEL）照射以其在关节炎、伤口愈合和肌肉拉伤方面的治疗效果而闻名，被应用于遭受视神经挤压伤的大鼠眼睛。视神经挤压伤导致前列腺素E2（PGE2）产量在体外长期升高（在12天的研究期间比对照值高1.8至3.9倍）。LEL照射本身对视神经产生PGE2的能力在体外没有影响；然而，对患有视神经挤压伤的眼睛进行LEL照射，在创伤后的晚期和即时阶段，分别在体外抑制了PGE2和白三烯B4产量增加的55%和75%。我们关于LEL照射对花生四烯酸代谢的抑制作用的发现让人联想到甾体和非甾体抗炎药的作用，并且可能首次表明了与LEL照射临床抗炎作用相关的潜在生化机制。
