Sauvé P, Mountney J, Khan T, De Beer J, Higgins B, Grover M
Portsmouth Hospitals NHS Trust, Queen Alexandra Hospital, Southwick Hill Road, Cosham PO6 3LY, United Kingdom.
J Bone Joint Surg Br. 2007 May;89(5):586-90. doi: 10.1302/0301-620X.89B5.18457.
Metal-on-metal bearings for total hip replacement (THR) are becoming increasingly popular. Improved wear characteristics mean that these articulations are being inserted into younger patients in the form of THR and resurfacing procedures. This has led to concerns regarding potential carcinogenicity because of the increased exposure to metal ions that the procedure brings. We have studied the serum cobalt and chromium concentrations in patients who had primary, well-fixed Ring metal-on-metal THRs for more than 30 years. The levels of cobalt and chromium were elevated by five and three times, respectively compared with those in our reference groups. Metal-on-metal articulations appear to be the source of metal ions throughout the life of the prosthesis. In three patients who had undergone revision of a previous metal-on-metal THR to a metal-on-polyethylene replacement the levels of metal ions were within the normal range. The elevations of cobalt and chromium ions seen in our study were comparable with those in patients with modern metal-on-metal THRs.
用于全髋关节置换（THR）的金属对金属轴承越来越受欢迎。改进的磨损特性意味着这些关节正以全髋关节置换和表面置换手术的形式植入年轻患者体内。由于该手术导致金属离子暴露增加，这引发了对潜在致癌性的担忧。我们研究了接受初次、固定良好的Ring金属对金属全髋关节置换超过30年的患者的血清钴和铬浓度。与我们的参考组相比，钴和铬的水平分别升高了五倍和三倍。金属对金属关节在假体的整个使用过程中似乎都是金属离子的来源。在三名将先前的金属对金属全髋关节置换翻修为金属对聚乙烯置换的患者中，金属离子水平在正常范围内。我们研究中观察到的钴和铬离子升高与现代金属对金属全髋关节置换患者的情况相当。
