Ling G V, Stabenfeldt G H, Comer K M, Gribble D H, Schechter R D
J Am Vet Med Assoc. 1979 Jun 1;174(11):1211-5.
The physical findings, clinical signs, age, breed and sex distributions, and laboratory data of 117 dogs with untreated Cushing's syndrome were reviewed. Poodles, Dachshunds, and Boxers of all ages were found to be at increased risk, as were dogs of all breeds greater than or equal to 6 years old. Polydipsia, polyuria, progressive bilaterally symmetric alopecia, and abdominal distention were the most frequently observed clinical signs and physical findings. Lymphopenia, eosinopenia, above normal values of serum alkaline phosphatase, serum cholesterol, and sulfobromphthalein dye retention, and below normal urine specific gravity were the most frequent abnormalities found in the laboratory data. About 50% of the dogs had urinary tract infections. Final diagnosis was established on the basis of abnormally high plasma corticosteroid values in response to an intramuscular injection of adrenocorticotropic hormone.
对117只未经治疗的库欣综合征犬的体格检查结果、临床体征、年龄、品种和性别分布以及实验室数据进行了回顾。发现各年龄段的贵宾犬、腊肠犬和拳师犬患病风险增加，所有6岁及以上的犬种也是如此。多饮、多尿、进行性双侧对称性脱毛和腹部膨隆是最常观察到的临床体征和体格检查结果。淋巴细胞减少、嗜酸性粒细胞减少、血清碱性磷酸酶、血清胆固醇和磺溴酞钠染料潴留高于正常值，以及尿比重低于正常值是实验室数据中最常见的异常情况。约50%的犬患有尿路感染。最终诊断是根据肌肉注射促肾上腺皮质激素后血浆皮质类固醇值异常升高来确定的。
